GSM-like radiofrequency exposure induces apoptosis via caspase-dependent pathway in infant rabbits

2016 · Mixed · Low evidence

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MixedLow evidencePaper 1356

Study snapshot

Publicationmanual · 2016

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

GSM-like radiofrequency exposure induces apoptosis via caspase-dependent pathway in infant rabbits Meral O, Ozgur E, Kismali G, Guler G, Alpay M, Sel T, Seyhan N. GSM-like radiofrequency exposure induces apoptosis via caspase-dependent pathway in infant rabbits. Bratisl Lek Listy. 2016;117(11):672-676. doi: 10.4149/BLL_2016_129. Abstract BACKGROUND: There have been several Radio Frequency (RF) field researches on various populations and groups of different ages in recent years. However, the most important group for research has been declared as the pregnant women and their babies. OBJECTIVE: The aim of the study was to analyse the effect on apoptotic factors of RF fields on newborn rabbit liver tissues. MATERIALS AND METHODS: Cytochrome c and AIF (Apoptosis Inducing Factor) levels were measured by western blot and caspase 1, 3 and 9 activities were measured by colorimetric method. RESULTS: Cytochrome c and AIF levels were not altered, but all caspase activities were increased in female infant rabbits that exposed to 1800 MHz GSM-like RF signals when they reached 1 month of age and caspase 1 and caspase 3 levels were decreased in male infant rabbits that exposed to 1800 MHz GSM-like RF signals between 15th and 22nd days of the gestational period. Results showed that 1800 MHz GSM-like RF exposure might lead to apoptosis in infant rabbit's liver tissues. CONCLUSION: According to the results, we suggest that postnatal RF exposure causes caspase dependent apoptosis in female infant rabbits liver tissues (Tab. 1, Fig. 2, Ref. 27). ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationInfant rabbits (female and male); prenatal exposure group described for male infant rabbits

Sample sizeNot supplied

ExposureRF · 1800 MHz · Postnatal exposure until 1 month of age (female infant rabbits); prenatal exposure during gestational days 15–22 (male infant rabbits)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Cytochrome c and AIF levels were not altered. Caspase 1, 3, and 9 activities were increased in female infant rabbits exposed to 1800 MHz GSM-like RF signals when they reached 1 month of age, while caspase 1 and caspase 3 levels were decreased in male infant rabbits exposed during gestational days 15–22. The authors state the results suggest 1800 MHz GSM-like RF exposure might lead to apoptosis in infant rabbit liver tissue, with postnatal exposure causing caspase-dependent apoptosis in females.

Outcomes measured

Apoptosis-related markers in liver tissue
Caspase 1 activity
Caspase 3 activity
Caspase 9 activity
Cytochrome c level
AIF (Apoptosis Inducing Factor) level

Limitations

Sample size not reported in abstract
Exposure metrics (e.g., SAR, power density) not reported in abstract
Exposure duration/details beyond timing windows not reported in abstract
Sex-specific and timing-specific effects reported (postnatal females vs gestational males), complicating interpretation

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 1800,
    "sar_wkg": null,
    "duration": "Postnatal exposure until 1 month of age (female infant rabbits); prenatal exposure during gestational days 15–22 (male infant rabbits)"
  },
  "population": "Infant rabbits (female and male); prenatal exposure group described for male infant rabbits",
  "sample_size": null,
  "outcomes": [
    "Apoptosis-related markers in liver tissue",
    "Caspase 1 activity",
    "Caspase 3 activity",
    "Caspase 9 activity",
    "Cytochrome c level",
    "AIF (Apoptosis Inducing Factor) level"
  ],
  "main_findings": "Cytochrome c and AIF levels were not altered. Caspase 1, 3, and 9 activities were increased in female infant rabbits exposed to 1800 MHz GSM-like RF signals when they reached 1 month of age, while caspase 1 and caspase 3 levels were decreased in male infant rabbits exposed during gestational days 15–22. The authors state the results suggest 1800 MHz GSM-like RF exposure might lead to apoptosis in infant rabbit liver tissue, with postnatal exposure causing caspase-dependent apoptosis in females.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure metrics (e.g., SAR, power density) not reported in abstract",
    "Exposure duration/details beyond timing windows not reported in abstract",
    "Sex-specific and timing-specific effects reported (postnatal females vs gestational males), complicating interpretation"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "GSM-like",
    "radiofrequency",
    "1800 MHz",
    "rabbit",
    "infant",
    "liver",
    "apoptosis",
    "caspase",
    "cytochrome c",
    "AIF"
  ],
  "suggested_hubs": [
    {
      "slug": "animal-studies",
      "weight": 0.9,
      "reason": "Experimental RF exposure study in infant rabbits assessing apoptosis markers."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.4149/bll_2016_129
PubMed: Not supplied

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