RF Safe

The effect of prenatal exposure to 1800 MHz electromagnetic field on calcineurin and bone development in rats.

Acta cirurgica brasileira · 2016 · Harm · Low evidence

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HarmLow evidencePaper 4873

Longer prenatal 1800 MHz EMF exposure was associated with reduced resting cartilage levels and increased numbers of apoptotic chondrocytes and myocytes. Calcineurin activity in bone and muscle tissues was reduced, and development of the femur, tibia, and ulna…

Study snapshot

PublicationActa cirurgica brasileira · 2016
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

PURPOSE: To investigated the effects of exposure to an 1800 MHz electromagnetic field (EMF) on bone development during the prenatal period in rats. METHODS: Pregnant rats in the experimental group were exposed to radiation for six, 12, and 24 hours daily for 20 days. No radiation was given to the pregnant rats in the control group. We distributed the newborn rats into four groups according to prenatal EMF exposure as follows: Group 1 was not exposed to EMF; groups 2, 3, and 4 were exposed to EMF for six, 12, and 24 hours a day, respectively. The rats were evaluated at the end of the 60th day following birth. RESULTS: Increasing the duration of EMF exposure during the prenatal period resulted in a significant reduction of resting cartilage levels and a significant increase in the number of apoptotic chondrocytes and myocytes. There was also a reduction in calcineurin activities in both bone and muscle tissues. We observed that the development of the femur, tibia, and ulna were negatively affected, especially with a daily EMF exposure of 24 hours. CONCLUSION: Bone and muscle tissue development was negatively affected due to prenatal exposure to 1800 MHz radiofrequency electromagnetic field.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationPregnant rats and their offspring (newborn rats evaluated at postnatal day 60)
Sample sizeNot supplied
ExposureRF · 1800 MHz · Prenatal exposure for 20 days; 6, 12, or 24 hours/day (by group)
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Longer prenatal 1800 MHz EMF exposure was associated with reduced resting cartilage levels and increased numbers of apoptotic chondrocytes and myocytes. Calcineurin activity in bone and muscle tissues was reduced, and development of the femur, tibia, and ulna was negatively affected, particularly with 24 hours/day exposure.

Outcomes measured

  • Bone development (femur, tibia, ulna)
  • Resting cartilage levels
  • Apoptotic chondrocytes
  • Apoptotic myocytes
  • Calcineurin activity in bone tissue
  • Calcineurin activity in muscle tissue

Limitations

  • Sample size not reported in abstract
  • Exposure metrics beyond frequency and hours/day (e.g., SAR/power density) not reported
  • Randomization/blinding not described
  • Only one animal species/model; generalizability to humans unclear
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 1800,
    "sar_wkg": null,
    "duration": "Prenatal exposure for 20 days; 6, 12, or 24 hours/day (by group)"
  },
  "population": "Pregnant rats and their offspring (newborn rats evaluated at postnatal day 60)",
  "sample_size": null,
  "outcomes": [
    "Bone development (femur, tibia, ulna)",
    "Resting cartilage levels",
    "Apoptotic chondrocytes",
    "Apoptotic myocytes",
    "Calcineurin activity in bone tissue",
    "Calcineurin activity in muscle tissue"
  ],
  "main_findings": "Longer prenatal 1800 MHz EMF exposure was associated with reduced resting cartilage levels and increased numbers of apoptotic chondrocytes and myocytes. Calcineurin activity in bone and muscle tissues was reduced, and development of the femur, tibia, and ulna was negatively affected, particularly with 24 hours/day exposure.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure metrics beyond frequency and hours/day (e.g., SAR/power density) not reported",
    "Randomization/blinding not described",
    "Only one animal species/model; generalizability to humans unclear"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "prenatal exposure",
    "1800 MHz",
    "radiofrequency",
    "EMF",
    "rats",
    "bone development",
    "calcineurin",
    "apoptosis",
    "cartilage",
    "femur",
    "tibia",
    "ulna",
    "muscle tissue"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1590/s0102-865020160020000001
PubMed: 26959616

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