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[Ultrastructural change of rabbit lens epithelial cells induced by low power level microwave radiation].

[Zhonghua yan ke za zhi] Chinese journal of ophthalmology · 2001 · Harm · Low evidence

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HarmLow evidencePaper 3902

Eight rabbit eyes exposed to low power microwave radiation (10 mW/cm^2) for 30 hours showed apparent ultrastructural changes in lens epithelial cells on transmission electron microscopy, including apoptosis-like morphological features. No obvious changes were…

Study snapshot

Publication[Zhonghua yan ke za zhi] Chinese journal of ophthalmology · 2001
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

OBJECTIVE: To study the ultrastructural change of rabbit lens epithelial cells with transmission electron microscope and to observe whether low power level microwave can induce the injury of rabbit lens. METHODS: Eight rabbit eyes were exposed to 10 mW/cm(2) low power level microwave radiation for 30 hours. Transmission electron microscope was used to observe the ultrastructural changes of the lens epithelial cells. The other eye was served as self-control. RESULTS: The ultrastructure of exposed lens epithelial cells changed apparently. The characteristic apoptosis cell morphological changes, such as small cell size, the decreased number of mitochondria, balloon-shaped mitochondria, etc can be seen. No obvious changes can be found in the protected self-control eyes. CONCLUSIONS: The low power level microwave (10 mW/cm(2)) can induce the ultrastructural changes of rabbit lens epithelial cells, this may be the appearance of early irreversible microwave radiation injury. In regard to the pathogenic mechanism, it is necessary to perform further investigations.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationRabbit eyes (lens epithelial cells)
Sample size8
Exposuremicrowave · 30 hours
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Eight rabbit eyes exposed to low power microwave radiation (10 mW/cm^2) for 30 hours showed apparent ultrastructural changes in lens epithelial cells on transmission electron microscopy, including apoptosis-like morphological features. No obvious changes were observed in the protected self-control eyes.

Outcomes measured

  • Ultrastructural changes in lens epithelial cells (TEM)
  • Apoptosis-like morphological changes (e.g., reduced cell size, decreased mitochondria, balloon-shaped mitochondria)

Limitations

  • Frequency of microwave exposure not reported
  • No SAR reported
  • Small sample size (8 rabbit eyes)
  • Outcome assessment limited to ultrastructural morphology; no functional/clinical endpoints reported
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "30 hours"
  },
  "population": "Rabbit eyes (lens epithelial cells)",
  "sample_size": 8,
  "outcomes": [
    "Ultrastructural changes in lens epithelial cells (TEM)",
    "Apoptosis-like morphological changes (e.g., reduced cell size, decreased mitochondria, balloon-shaped mitochondria)"
  ],
  "main_findings": "Eight rabbit eyes exposed to low power microwave radiation (10 mW/cm^2) for 30 hours showed apparent ultrastructural changes in lens epithelial cells on transmission electron microscopy, including apoptosis-like morphological features. No obvious changes were observed in the protected self-control eyes.",
  "effect_direction": "harm",
  "limitations": [
    "Frequency of microwave exposure not reported",
    "No SAR reported",
    "Small sample size (8 rabbit eyes)",
    "Outcome assessment limited to ultrastructural morphology; no functional/clinical endpoints reported"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "low power",
    "rabbit",
    "lens epithelial cells",
    "transmission electron microscopy",
    "ultrastructure",
    "apoptosis"
  ],
  "suggested_hubs": [
    {
      "slug": "animal-studies",
      "weight": 0.9,
      "reason": "Experimental microwave exposure study in rabbits assessing biological effects."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 11864393

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