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Influence of CW microwave radiation on in vitro release of enzymes from retinol- treated hepatic lysosomes.

Cell biophysics · 1981 · No effect · Low evidence

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No effectLow evidencePaper 6015

In vitro exposure of hepatic lysosomes to 2450 MHz CW microwave radiation at 10 or 100 mW/g for 60 minutes during retinol treatment had no effect on release of beta-glucuronidase, cathepsin D, or acid phosphatase. Pre-irradiation (40 min) followed by 20 min r…

Study snapshot

PublicationCell biophysics · 1981
Study typein_vitro
Reported directionNo effect
Evidence ratingLow

Abstract

Hepatic lysosomes were exposed in vitro to microwave radiation (2450 MHz) either prior to or simultaneously with treatment with retinol (vitamin A), and the release of the lysosomal enzymes, beta-glucuronidase, acid phosphatase, and cathepsin D, determined. A 60-min microwave exposure (10 or 100 mW/g) of retinol-treated lysosomes had no effect on the amount of release of beta-glucuronidase, cathepsin D, or acid phosphatase. In addition, 10 and 100 mW/g irradiation of lysosome fractions for 40 min prior to a 20-min retinol and microwave treatment, had no influence on the release of these enzymes. Finally, the effect of microwave radiation on the loss of latency of acid phosphatase and beta-glucuronidase from retinol-treated lysosomes was determined. Microwave radiation had no influence on the rate of appearance of these enzymes in the suspending medium. The results indicate that microwave radiation had no effect on the retinol-induced lysosomal enzyme release.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionno_effect
PopulationHepatic lysosomes (in vitro)
Sample sizeNot supplied
Exposuremicrowave · 2450 MHz · 60 min; 40 min prior + 20 min simultaneous (retinol + microwave)
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In vitro exposure of hepatic lysosomes to 2450 MHz CW microwave radiation at 10 or 100 mW/g for 60 minutes during retinol treatment had no effect on release of beta-glucuronidase, cathepsin D, or acid phosphatase. Pre-irradiation (40 min) followed by 20 min retinol plus microwave treatment also showed no influence on enzyme release, and microwave radiation did not affect the rate of appearance (loss of latency) of acid phosphatase or beta-glucuronidase.

Outcomes measured

  • Release of lysosomal enzymes (beta-glucuronidase, acid phosphatase, cathepsin D)
  • Loss of latency / rate of appearance of acid phosphatase and beta-glucuronidase in suspending medium

Limitations

  • In vitro lysosome preparation; may not generalize to in vivo conditions
  • Sample size and replication not reported in abstract
  • Exposure metric reported as mW/g; SAR not explicitly stated
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": "60 min; 40 min prior + 20 min simultaneous (retinol + microwave)"
  },
  "population": "Hepatic lysosomes (in vitro)",
  "sample_size": null,
  "outcomes": [
    "Release of lysosomal enzymes (beta-glucuronidase, acid phosphatase, cathepsin D)",
    "Loss of latency / rate of appearance of acid phosphatase and beta-glucuronidase in suspending medium"
  ],
  "main_findings": "In vitro exposure of hepatic lysosomes to 2450 MHz CW microwave radiation at 10 or 100 mW/g for 60 minutes during retinol treatment had no effect on release of beta-glucuronidase, cathepsin D, or acid phosphatase. Pre-irradiation (40 min) followed by 20 min retinol plus microwave treatment also showed no influence on enzyme release, and microwave radiation did not affect the rate of appearance (loss of latency) of acid phosphatase or beta-glucuronidase.",
  "effect_direction": "no_effect",
  "limitations": [
    "In vitro lysosome preparation; may not generalize to in vivo conditions",
    "Sample size and replication not reported in abstract",
    "Exposure metric reported as mW/g; SAR not explicitly stated"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "2450 MHz",
    "continuous wave",
    "in vitro",
    "hepatic lysosomes",
    "retinol",
    "vitamin A",
    "beta-glucuronidase",
    "acid phosphatase",
    "cathepsin D",
    "lysosomal enzyme release"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/bf02788133
PubMed: 6168380

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