Modulation of antioxidant enzyme gene expression by extremely low frequency electromagnetic field in post-stroke patients.

Scandinavian journal of clinical and laboratory investigation · 2018 · Benefit · Low evidence

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BenefitLow evidencePaper 5503

In 48 post-stroke patients, those receiving additional ELF-EMF therapy showed a significant increase in mRNA expression of CAT, SOD1, SOD2, GPx1, and GPx4 after therapy, compared with the non-ELF-EMF group. The authors interpret this as enhanced antioxidant d…

Study snapshot

PublicationScandinavian journal of clinical and laboratory investigation · 2018

Study typeother

Reported directionBenefit

Evidence ratingLow

Abstract

Oxidative stress plays the most important role in the pathogenesis of stroke. Extremely low frequency electromagnetic field (ELF-EMF) therapy may be complementary in post-stroke therapy, as it modulates oxidative stress. The aim of this study was to evaluate the messenger ribonucleic acid (mRNA) levels of certain antioxidant genes in post-stroke patients given ELF-EMF therapy. Forty-eight post-stroke patients were divided into two groups: an ELF-EMF group and a non-ELF-EMF group. All patients underwent the same program of physical therapy, but the ELF-EMF group was additionally given ELF-EMF treatment. In order to determine the level of gene expression, we evaluated the level of mRNA expression of catalase, superoxide dismutase, and glutathione peroxidase. We observed that after ELF-EMF therapy, the mRNA expression of the studied genes (CAT, SOD1, SOD2, GPx1, and GPx4) significantly increased, which enhanced the antioxidant defence of the body. ELF-EMF therapy intensifies the endogenous antioxidant system by increasing the mRNA expression of genes encoding antioxidant enzymes and enhances the effectiveness of post-stroke patient therapy.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionbenefit

PopulationPost-stroke patients

Sample size48

ExposureELF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

mRNA expression of antioxidant enzyme genes (CAT, SOD1, SOD2, GPx1, GPx4)
Antioxidant defence/endogenous antioxidant system (as inferred from gene expression changes)

Limitations

No ELF-EMF exposure parameters reported (e.g., frequency, intensity, session duration).
Study design details not provided in abstract (e.g., randomization, blinding, allocation method).
Clinical outcomes are not described; outcomes reported are gene expression measures.

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": "ELF",
    "source": "therapy",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Post-stroke patients",
  "sample_size": 48,
  "outcomes": [
    "mRNA expression of antioxidant enzyme genes (CAT, SOD1, SOD2, GPx1, GPx4)",
    "Antioxidant defence/endogenous antioxidant system (as inferred from gene expression changes)"
  ],
  "main_findings": "In 48 post-stroke patients, those receiving additional ELF-EMF therapy showed a significant increase in mRNA expression of CAT, SOD1, SOD2, GPx1, and GPx4 after therapy, compared with the non-ELF-EMF group. The authors interpret this as enhanced antioxidant defence and improved effectiveness of post-stroke therapy.",
  "effect_direction": "benefit",
  "limitations": [
    "No ELF-EMF exposure parameters reported (e.g., frequency, intensity, session duration).",
    "Study design details not provided in abstract (e.g., randomization, blinding, allocation method).",
    "Clinical outcomes are not described; outcomes reported are gene expression measures."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency electromagnetic field",
    "ELF-EMF",
    "stroke",
    "post-stroke therapy",
    "oxidative stress",
    "antioxidant enzymes",
    "gene expression",
    "catalase",
    "superoxide dismutase",
    "glutathione peroxidase",
    "mRNA"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.05,
      "reason": "ELF-EMF is studied, but this appears to be therapeutic exposure rather than occupational; hub match is weak."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/00365513.2018.1542540
PubMed: 30755096

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