Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water

2023 · Harm · Low evidence

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HarmLow evidencePaper 542

Study snapshot

Publicationmanual · 2023

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water Elmoslemany AM, Ghamry HI, Awad AA, El-Kholy RI, Almami ISM, Alyamani NM, Zedan AMG. Liver tissues oxidative status, epigenetic and molecular characteristics in rats administered magnetic and microwave treated water. Sci Rep. 2023 Mar 16;13(1):4406. doi: 10.1038/s41598-023-31168-9. Abstract Physical and chemical changes in the natural of water may affect biological organisms. In this study, we highlight the effect of magnetized-water and microwave-water on rats' liver tissues. Three groups of albino rats were separated. The first, rats were administered tap-water. The second, rats were administered magnetized-water. The third, rats were administered microwave-water. After two months, the results revealed a significant increase in liver functioning enzymes' levels and bilirubin in rats administered microwave-water, compared to tap- and magnetic-water. In relation to oxidative stress, there was a significant increase and decrease in oxidative and antioxidant parameters respectively in liver tissues of rat's administrated microwave-water. At the molecular level, there was a significant down-regulation in Metallothionein, CYP genes in magnetic-water compared to tap-water. Rats administered microwave-water have shown a significant down-regulation in GST, Metallothionein and CYP genes' expression, however, Amylase and HDAC3 genes were significantly up- regulated, compared to the other groups. The intake of microwave-water resulted in notable histopathological changes in liver tissues. Rats administered magnetic-water showed no clear changes in their liver tissues. In summary, microwave-water induced stress and epigenetic effects compared with magnetic-water and tap- water. Also, magnetic-water produced from the higher magnetic power had no side effect on liver tissues. Open access paper: nature.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

Populationalbino rats

Sample sizeNot supplied

Exposure2 months

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

After two months, rats administered microwave-treated water showed significantly increased liver function enzymes and bilirubin versus tap- and magnetized-water groups. Microwave-water was associated with increased oxidative parameters and decreased antioxidant parameters in liver tissue, down-regulation of GST/Metallothionein/CYP genes and up-regulation of Amylase and HDAC3, along with notable liver histopathological changes; magnetized-water showed no clear liver tissue changes.

Outcomes measured

Liver function enzymes levels
Bilirubin
Oxidative stress parameters in liver tissue (oxidative and antioxidant parameters)
Gene expression (Metallothionein, CYP, GST, Amylase, HDAC3)
Histopathological changes in liver tissue

Limitations

Sample size not reported in abstract
Microwave and magnetic treatment parameters (e.g., frequency, field strength, exposure metrics) not reported in abstract
Details of oxidative/antioxidant markers and assay methods not provided in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "microwave treated water; magnetized water",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "2 months"
  },
  "population": "albino rats",
  "sample_size": null,
  "outcomes": [
    "Liver function enzymes levels",
    "Bilirubin",
    "Oxidative stress parameters in liver tissue (oxidative and antioxidant parameters)",
    "Gene expression (Metallothionein, CYP, GST, Amylase, HDAC3)",
    "Histopathological changes in liver tissue"
  ],
  "main_findings": "After two months, rats administered microwave-treated water showed significantly increased liver function enzymes and bilirubin versus tap- and magnetized-water groups. Microwave-water was associated with increased oxidative parameters and decreased antioxidant parameters in liver tissue, down-regulation of GST/Metallothionein/CYP genes and up-regulation of Amylase and HDAC3, along with notable liver histopathological changes; magnetized-water showed no clear liver tissue changes.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract",
    "Microwave and magnetic treatment parameters (e.g., frequency, field strength, exposure metrics) not reported in abstract",
    "Details of oxidative/antioxidant markers and assay methods not provided in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave-treated water",
    "magnetized water",
    "rats",
    "liver",
    "oxidative stress",
    "antioxidant parameters",
    "gene expression",
    "epigenetic",
    "HDAC3",
    "histopathology"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1038/s41598-023-31168-9
PubMed: Not supplied

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