Endometrial apoptosis induced by a 900-MHz mobile phone: preventive effects of vitamins E and C.

Advances in therapy · 2006 · Harm · Low evidence

← Research stream

HarmLow evidencePaper 5090

Rats exposed to 900 MHz EMF (30 min/day for 30 days) showed increased malondialdehyde levels in endometrial tissue and evidence of apoptosis. In the vitamin E+C treated exposed group, oxidative tissue injury and apoptosis were reported as ameliorated compared…

Study snapshot

PublicationAdvances in therapy · 2006

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Numerous reports have described the effects induced by an electromagnetic field (EMF) in various cellular systems. The purposes of this study were to examine oxidative stress that promotes production of reactive oxygen species induced by a 900-megahertz (MHz) mobile phone and the possible ameliorating effects of vitamins E and C on endometrial tissue against EMF-induced endometrial impairment and apoptosis in rats. Animals were randomly grouped as follows: (1) sham-operated control group (n=8), (2) 900 MHz EMF-exposed group (n=8; 30 min/d for 30 d), and (3) 900 MHz EMF-exposed group, treated with vitamins E and C (n=8; 50 mg/kg intramuscularly and 20 mg/kg body weight intraperitoneally before daily EMF exposure). Malondialdehyde (an index of lipid peroxidation) was used as a marker of oxidative stress-induced endometrial impairment; Bcl-2, Bax, caspase-3, and caspase-8 were assessed immunohistochemically. In this study, increased malondialdehyde levels in endometrial tissue and apoptosis illustrated the role of the oxidative mechanism induced by exposure to a 900-MHz mobile phone-like device and vitamins E and C; via free radical scavenging and antioxidant properties, oxidative tissue injury and apoptosis were ameliorated in rat endometrium. In conclusion, exposure to 900-MHz radiation emitted by mobile phones may cause endometrial apoptosis and oxidative stress, but treatment with vitamins E and C can diminish these changes and may have a beneficial effect in preventing endometrial changes in rats.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationRats (endometrial tissue)

Sample size24

ExposureRF · 900 MHz · 30 min/day for 30 days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Oxidative stress (malondialdehyde/lipid peroxidation)
Endometrial apoptosis
Immunohistochemical markers: Bcl-2, Bax, caspase-3, caspase-8
Effect of vitamins E and C on EMF-associated changes

Limitations

No SAR or dosimetry details reported in the abstract
Animal study; generalizability to humans is unclear
Small group sizes (n=8 per group)
Exposure described as a 'mobile phone-like device' without further characterization in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "30 min/day for 30 days"
  },
  "population": "Rats (endometrial tissue)",
  "sample_size": 24,
  "outcomes": [
    "Oxidative stress (malondialdehyde/lipid peroxidation)",
    "Endometrial apoptosis",
    "Immunohistochemical markers: Bcl-2, Bax, caspase-3, caspase-8",
    "Effect of vitamins E and C on EMF-associated changes"
  ],
  "main_findings": "Rats exposed to 900 MHz EMF (30 min/day for 30 days) showed increased malondialdehyde levels in endometrial tissue and evidence of apoptosis. In the vitamin E+C treated exposed group, oxidative tissue injury and apoptosis were reported as ameliorated compared with exposure alone.",
  "effect_direction": "harm",
  "limitations": [
    "No SAR or dosimetry details reported in the abstract",
    "Animal study; generalizability to humans is unclear",
    "Small group sizes (n=8 per group)",
    "Exposure described as a 'mobile phone-like device' without further characterization in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "900 MHz",
    "mobile phone",
    "RF-EMF",
    "rats",
    "endometrium",
    "apoptosis",
    "oxidative stress",
    "malondialdehyde",
    "Bcl-2",
    "Bax",
    "caspase-3",
    "caspase-8",
    "vitamin E",
    "vitamin C",
    "antioxidants"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones",
      "weight": 0.9,
      "reason": "Exposure is 900 MHz radiation from a mobile phone-like device."
    }
  ]
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/bf02850217
PubMed: 17276964

Read the original paper →

Related papers

← Back to the Research Library