Modulatory effect of 900 MHz radiation on biochemical and reproductive parameters in rats

2018 · Harm · Low evidence

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HarmLow evidencePaper 2023

Study snapshot

Publicationmanual · 2018

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Modulatory effect of 900 MHz radiation on biochemical and reproductive parameters in rats Narayanan SN, Lukose ST, Arun G, Mohapatra N, Pamala J, Concessao PL, Jetti R, Kedage V, Nalini K, Bhat PG. Modulatory effect of 900 MHz radiation on biochemical and reproductive parameters in rats. Bratisl Lek Listy. 2018;119(9):581-587. doi: 10.4149/BLL_2018_105. Abstract In the present study, the effect of 900 MHz radiation exposure on blood biochemical and reproductive parameters was evaluated in adolescent rats. Male albino Wistar rats (8-10 weeks of age) were exposed to 900 MHz radiation (1hr/day, power density - 146.60 µW/cm2) from a mobile phone for 28 days. On 29th day the animals were euthanized and malondialdehyde (MDA), total antioxidants (TA) levels and Glutathione-S transferase (GST) activity were studied in the blood. Reproductive parameters such as total sperm count, percentage of non-motile sperms, and sperm morphology were determined. Testes sections were stained with H(et)E staining and their cellular integrity was evaluated. Caspase-3 activity in the testes was also determined. MDA concentration was increased but TA levels and GST activity were not found to be different in 900 MHz group compared to controls. Sperm motility was found to be slightly reduced in 900 MHz group. Percentage of abnormal sperm was significantly elevated in 900 MHz group. Additionally, loss of germ cells particularly spermatocytes and spermatids was found in the testes of 900 MHz group. Testes caspase-3 activity was slightly elevated in 900 MHz exposed rats. Chronic 900 MHz exposure induced oxidative damage in the blood and lead to alterations in reproductive parameters in rats (Fig. 4, Ref. 33). Open access paper: bit.ly

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationAdolescent male albino Wistar rats (8–10 weeks old)

Sample sizeNot supplied

ExposureRF · 900 MHz · 1 hr/day for 28 days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Rats exposed to 900 MHz radiation from a mobile phone (1 hr/day for 28 days; power density 146.60 µW/cm2) had increased blood MDA, while TA levels and GST activity were not different versus controls. Sperm motility was slightly reduced and abnormal sperm percentage was significantly elevated; testes showed loss of germ cells (notably spermatocytes and spermatids) and caspase-3 activity was slightly elevated.

Outcomes measured

Blood malondialdehyde (MDA)
Total antioxidants (TA)
Glutathione-S transferase (GST) activity
Total sperm count
Percentage of non-motile sperm / sperm motility
Sperm morphology / abnormal sperm percentage
Testes histology (H&E; cellular integrity; germ cell loss)
Testes caspase-3 activity

Limitations

Sample size not reported in abstract
Specific exposure setup details beyond power density (e.g., distance, modulation, dosimetry/SAR) not provided in abstract
Magnitude/statistical details for several outcomes (e.g., sperm motility, caspase-3) described as 'slightly' without quantitative values

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "1 hr/day for 28 days"
  },
  "population": "Adolescent male albino Wistar rats (8–10 weeks old)",
  "sample_size": null,
  "outcomes": [
    "Blood malondialdehyde (MDA)",
    "Total antioxidants (TA)",
    "Glutathione-S transferase (GST) activity",
    "Total sperm count",
    "Percentage of non-motile sperm / sperm motility",
    "Sperm morphology / abnormal sperm percentage",
    "Testes histology (H&E; cellular integrity; germ cell loss)",
    "Testes caspase-3 activity"
  ],
  "main_findings": "Rats exposed to 900 MHz radiation from a mobile phone (1 hr/day for 28 days; power density 146.60 µW/cm2) had increased blood MDA, while TA levels and GST activity were not different versus controls. Sperm motility was slightly reduced and abnormal sperm percentage was significantly elevated; testes showed loss of germ cells (notably spermatocytes and spermatids) and caspase-3 activity was slightly elevated.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract",
    "Specific exposure setup details beyond power density (e.g., distance, modulation, dosimetry/SAR) not provided in abstract",
    "Magnitude/statistical details for several outcomes (e.g., sperm motility, caspase-3) described as 'slightly' without quantitative values"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "900 MHz",
    "RF radiation",
    "mobile phone",
    "rats",
    "oxidative stress",
    "malondialdehyde",
    "antioxidants",
    "GST",
    "sperm motility",
    "abnormal sperm",
    "testes histology",
    "caspase-3"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones",
      "weight": 0.9,
      "reason": "Exposure described as 900 MHz radiation from a mobile phone."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.4149/bll_2018_105
PubMed: Not supplied

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