Synaptosome behaviour is unaffected by weak pulsed electromagnetic fields.

Bioelectromagnetics · 2007 · No effect · Low evidence

← Research stream

No effectLow evidencePaper 5066

After 2 h exposure to 50-Hz EMFs with a peak magnetic field of 2 mT, synaptosomal O2 consumption and ATP production were unchanged. Ca(2+) concentration decreased slowly and membrane depolarisation was slight and not significant; free iron release remained un…

Study snapshot

PublicationBioelectromagnetics · 2007

Study typeanimal

Reported directionNo effect

Evidence ratingLow

Abstract

The present study examined the effect on rat cortical synaptosomes of a 2 h exposure to 50-Hz electromagnetic fields (EMFs) with a peak magnetic field of 2 mT. We measured modifications of synaptosomal mitochondrial respiration rate, ATP production, membrane potential, intrasynaptosomal Ca(2+) concentration and free iron release. The O(2) consumption remained unvaried in exposed synaptosomes at about 2 nM O(2)/min/mg proteins; ATP production was also unchanged. The intrasynaptosomal Ca(2+) concentration decreased slowly and there was a slight, but non-significant, depolarisation of the synaptosomal membrane. Finally, the free iron release by synaptosomal suspensions, a useful predictor of neuro-developmental outcome, remained unchanged after EMF exposure. On the whole, our results indicate that the physiological behaviour of cortical synaptosomes is not affected by weak pulsed EMFs.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionno_effect

PopulationRat cortical synaptosomes

Sample sizeNot supplied

ExposureELF · 0.05 MHz · 2 h

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Synaptosomal mitochondrial respiration rate (O2 consumption)
ATP production
Synaptosomal membrane potential
Intrasynaptosomal Ca(2+) concentration
Free iron release

Limitations

Sample size not reported in provided abstract/metadata
Exposure described as weak pulsed EMFs but pulse characteristics not detailed in provided abstract
Ex vivo synaptosome preparation; generalizability to whole-animal or human outcomes not addressed in provided abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "2 h"
  },
  "population": "Rat cortical synaptosomes",
  "sample_size": null,
  "outcomes": [
    "Synaptosomal mitochondrial respiration rate (O2 consumption)",
    "ATP production",
    "Synaptosomal membrane potential",
    "Intrasynaptosomal Ca(2+) concentration",
    "Free iron release"
  ],
  "main_findings": "After 2 h exposure to 50-Hz EMFs with a peak magnetic field of 2 mT, synaptosomal O2 consumption and ATP production were unchanged. Ca(2+) concentration decreased slowly and membrane depolarisation was slight and not significant; free iron release remained unchanged.",
  "effect_direction": "no_effect",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Exposure described as weak pulsed EMFs but pulse characteristics not detailed in provided abstract",
    "Ex vivo synaptosome preparation; generalizability to whole-animal or human outcomes not addressed in provided abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "50 Hz",
    "2 mT",
    "synaptosomes",
    "rat cortex",
    "mitochondrial respiration",
    "ATP",
    "membrane potential",
    "calcium",
    "iron release"
  ],
  "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.20322
PubMed: 17497690

Read the original paper →

Related papers

← Back to the Research Library