Comparison of ELF-EMFs stimulation with current stimulation on the regulation of LTP of SC-CA1 synapses in young rat hippocampus

International journal of radiation biology · 2021 · Harm · Low evidence

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HarmLow evidencePaper 1159

Study snapshot

PublicationInternational journal of radiation biology · 2021

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Comparison of ELF-EMFs stimulation with current stimulation on the regulation of LTP of SC-CA1 synapses in young rat hippocampus Yu Zheng, Wenjun Zhao, Xiaoxu Ma, Lei Dong, Lei Tian, Mei Zhou. Comparison of ELF-EMFs stimulation with current stimulation on the regulation of LTP of SC-CA1 synapses in young rat hippocampus. Int J Radiat Biol. 2021 May 10;1-21. doi: 10.1080/09553002.2021.1928781. Abstract Background: Long-term potentiation (LTP) is an important functional indicator for studying synaptic plasticity. Extremely low frequency electromagnetic fields (ELF-EMFs) are a physical means to regulate LTP. Time-varying magnetic fields induce induced currents. It is unknown which of the two parameters is the key factor when LTP is regulated by the magnetic field.New Method: A method is proposed for calculating the current value induced by ELF-EMFs. Then, a comparison of ELF-EMFs stimulation (100 Hz/2 mT and 200 Hz/2 mT) with current stimulation (0.1 μA and 0.2 μA) on the regulation of theta-burst or high-frequency stimulation (TBS/HFS)-LTP was performed. Results: The LTP after ELF-EMFs and μA current regulation was significantly reduced compared with the corresponding value in the control group. The regulatory effect of 100 Hz/2 mT ELF-EMFs on LTP was stronger than 200 Hz/2 mT. However, the regulatory level of the currents (0.1 μA, 0.2 μA) was similar; the effect of 0.1 μA current was similar to that of 100 Hz/2 mT ELF-EMFs, while 0.2 μA had a stronger regulatory effect than that of 200 Hz/2 mT on HFS-LTP.Comparison with Existing Methods: Most of the existing methods were used to calculate the induced current in human models, while a calculation model of the induced current in the rat brain slice induced by ELF-EMFs was established in this work, which is more accurate than the existing methods. Conclusions: This work demonstrated that both current and ELF EMFs stimulation reduced LTP. However, their effect was not exactly the same, indicating that the regulatory effect of ELF-EMFs on LTP is not entirely deriving from the induced current, since its magnetic mechanism might have played a certain role. pubmed.ncbi.nlm.nih.gov

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Study typeanimal

Effect directionharm

PopulationYoung rat hippocampus (SC-CA1 synapses; brain slice model implied)

Sample sizeNot supplied

ExposureELF

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Compared with control, LTP after ELF-EMF stimulation (100 Hz/2 mT; 200 Hz/2 mT) and after microampere current stimulation (0.1 μA; 0.2 μA) was significantly reduced. The 100 Hz/2 mT ELF-EMF effect on LTP was stronger than 200 Hz/2 mT; current effects at 0.1 and 0.2 μA were described as similar overall, with 0.1 μA similar to 100 Hz/2 mT and 0.2 μA stronger than 200 Hz/2 mT for HFS-LTP.

Outcomes measured

Long-term potentiation (LTP) of SC-CA1 synapses
TBS-LTP
HFS-LTP
Induced current calculation/modeling in rat brain slice

Limitations

Sample size not reported in provided abstract/metadata
Exposure duration and detailed experimental conditions not reported in provided abstract/metadata
Animal/brain-slice findings may not generalize to humans

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "laboratory stimulation (magnetic field) and induced/current stimulation",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Young rat hippocampus (SC-CA1 synapses; brain slice model implied)",
  "sample_size": null,
  "outcomes": [
    "Long-term potentiation (LTP) of SC-CA1 synapses",
    "TBS-LTP",
    "HFS-LTP",
    "Induced current calculation/modeling in rat brain slice"
  ],
  "main_findings": "Compared with control, LTP after ELF-EMF stimulation (100 Hz/2 mT; 200 Hz/2 mT) and after microampere current stimulation (0.1 μA; 0.2 μA) was significantly reduced. The 100 Hz/2 mT ELF-EMF effect on LTP was stronger than 200 Hz/2 mT; current effects at 0.1 and 0.2 μA were described as similar overall, with 0.1 μA similar to 100 Hz/2 mT and 0.2 μA stronger than 200 Hz/2 mT for HFS-LTP.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Exposure duration and detailed experimental conditions not reported in provided abstract/metadata",
    "Animal/brain-slice findings may not generalize to humans"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "extremely low frequency",
    "magnetic field",
    "100 Hz",
    "200 Hz",
    "2 mT",
    "induced current",
    "0.1 μA",
    "0.2 μA",
    "hippocampus",
    "SC-CA1",
    "synaptic plasticity",
    "long-term potentiation",
    "TBS",
    "HFS"
  ],
  "suggested_hubs": [
    {
      "slug": "mechanisms-neurophysiology",
      "weight": 0.86,
      "reason": "Assesses ELF-EMF and current stimulation effects on hippocampal LTP (synaptic plasticity mechanism)."
    },
    {
      "slug": "elf-emf",
      "weight": 0.8,
      "reason": "Uses extremely low frequency magnetic fields (100–200 Hz, 2 mT) and compares to induced/current stimulation."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/09553002.2021.1928781
PubMed: 33970763

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