Effects of ELF-EMF on brain proteins in mice.

Electromagnetic biology and medicine · 2009 · Mixed · Low evidence

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MixedLow evidencePaper 4962

Mice exposed for 4 days to a 50 Hz magnetic field (Bm = 2 mT) showed no change in c-Fos expression, while c-Jun expression decreased after exposure. The reported results did not depend on sex.

Study snapshot

PublicationElectromagnetic biology and medicine · 2009

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Effect of electromagnetic low frequency fields was studied on mice. We analyzed level of protein in brain of mouse. The levels of c-Jun and c-Fos in brains were measured using Western-blot techniques. Female and male laboratory mice were exposed for 4 days to magnetic field (Bm = 2 mT, f = 50 Hz). The exposure took place in cylindrical coil at laboratory temperature. After the experiment they were sacrificed and the level of protein c-Jun and c-Fos in different parts of brain were estimated. The expression of c-Fos was not affected by magnetic field on the other hand the expression of c-Jun decreased after magnetic field exposure. The results did not depend on sex of mice.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationFemale and male laboratory mice

Sample sizeNot supplied

ExposureELF · 0.05 MHz · 4 days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Mice exposed for 4 days to a 50 Hz magnetic field (Bm = 2 mT) showed no change in c-Fos expression, while c-Jun expression decreased after exposure. The reported results did not depend on sex.

Outcomes measured

Brain protein expression levels of c-Jun
Brain protein expression levels of c-Fos

Limitations

Sample size not reported in abstract
Only two protein markers (c-Jun, c-Fos) assessed
Exposure duration limited to 4 days
Specific brain regions assessed are not detailed in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "other",
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "4 days"
  },
  "population": "Female and male laboratory mice",
  "sample_size": null,
  "outcomes": [
    "Brain protein expression levels of c-Jun",
    "Brain protein expression levels of c-Fos"
  ],
  "main_findings": "Mice exposed for 4 days to a 50 Hz magnetic field (Bm = 2 mT) showed no change in c-Fos expression, while c-Jun expression decreased after exposure. The reported results did not depend on sex.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Only two protein markers (c-Jun, c-Fos) assessed",
    "Exposure duration limited to 4 days",
    "Specific brain regions assessed are not detailed in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "ELF-EMF",
    "50 Hz",
    "magnetic field",
    "2 mT",
    "mice",
    "brain",
    "c-Jun",
    "c-Fos",
    "Western blot"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/15368370802711870
PubMed: 19337900

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