A new theoretical model for transmembrane potential and ion currents induced in a spherical cell under low frequency electromagnetic field.

Bioelectromagnetics · 2016 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 4840

The paper presents a new theoretical model to calculate ionic current changes induced by time-varying EMF exposure using equations originating from the Nernst-Plank equations, and then calculates transmembrane potential changes using the Hodgkin-Huxley model.

Study snapshot

PublicationBioelectromagnetics · 2016

Study typeother

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Time-varying electromagnetic fields (EMF) can induce some physiological effects in neuronal tissues, which have been explored in many applications such as transcranial magnetic stimulation. Although transmembrane potentials and induced currents have already been the subjects of many theoretical studies, most previous works about this topic are mainly completed by utilizing Maxwell's equations, often by solving a Laplace equation. In previous studies, cells were often considered to be three-compartment models with different electroconductivities in different regions (three compartments are often intracellular regions, membrane, and extracellular regions). However, models like that did not take dynamic ion channels into consideration. Therefore, one cannot obtain concrete ionic current changes such as potassium current change or sodium current change by these models. The aim of the present work is to present a new and more detailed model for calculating transmembrane potentials and ionic currents induced by time-varying EMF. Equations used in the present paper originate from Nernst-Plank equations, which are ionic current-related equations. The main work is to calculate ionic current changes induced by EMF exposure, and then transmembrane potential changes are calculated with Hodgkin-Huxley model. Bioelectromagnetics. 37:481-492, 2016. © 2016 Wiley Periodicals, Inc.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionunclear

PopulationNot supplied

Sample sizeNot supplied

ExposureELF

Evidence strengthInsufficientConfidence: 66% · Peer reviewed: yes

Main findings

Outcomes measured

Transmembrane potential (modeled)
Ion currents (modeled), including potassium and sodium currents

Limitations

The abstract does not report quantitative results or validation against experimental data.
Exposure parameters (e.g., field strength, frequency) are not specified in the abstract.
Model assumptions and boundary conditions are not described in the abstract.

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Transmembrane potential (modeled)",
    "Ion currents (modeled), including potassium and sodium currents"
  ],
  "main_findings": "The paper presents a new theoretical model to calculate ionic current changes induced by time-varying EMF exposure using equations originating from the Nernst-Plank equations, and then calculates transmembrane potential changes using the Hodgkin-Huxley model.",
  "effect_direction": "unclear",
  "limitations": [
    "The abstract does not report quantitative results or validation against experimental data.",
    "Exposure parameters (e.g., field strength, frequency) are not specified in the abstract.",
    "Model assumptions and boundary conditions are not described in the abstract."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "time-varying electromagnetic fields",
    "low frequency electromagnetic field",
    "transmembrane potential",
    "ion currents",
    "Nernst-Plank equations",
    "Hodgkin-Huxley model",
    "spherical cell",
    "theoretical model"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.21993
PubMed: 27438778

Read the original paper →

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