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Low Frequency Electromagnetic Field Conditioning Protects against I/R Injury and Contractile Dysfunction in the Isolated Rat Heart.

BioMed research international · 2015 · Benefit · Low evidence

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BenefitLow evidencePaper 4779

In isolated rat hearts subjected to ischemia/reperfusion, LF-EMF exposure prevented a decrease in rate pressure product and increased LVDP, with no effect on coronary flow. Elevated TnI and IL-6 in I/R hearts returned to baseline levels with LF-EMF, and reduc…

Study snapshot

PublicationBioMed research international · 2015
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

Low frequency electromagnetic field (LF-EMF) decreases the formation of reactive oxygen species, which are key mediators of ischemia/reperfusion (I/R) injury. Therefore, we hypothesized that the LF-EMF protects contractility of hearts subjected to I/R injury. Isolated rat hearts were subjected to 20 min of global no-flow ischemia, followed by 30 min reperfusion, in the presence or absence of LF-EMF. Coronary flow, heart rate, left ventricular developed pressure (LVDP), and rate pressure product (RPP) were determined for evaluation of heart mechanical function. The activity of cardiac matrix metalloproteinase-2 (MMP-2) and the contents of coronary effluent troponin I (TnI) and interleukin-6 (IL-6) were measured as markers of heart injury. LF-EMF prevented decreased RPP in I/R hearts, while having no effect on coronary flow. In addition, hearts subjected to I/R exhibited significantly increased LVDP when subjected to LF-EMF. Although TnI and IL-6 levels were increased in I/R hearts, their levels returned to baseline aerobic levels in I/R hearts subjected to LF-EMF. The reduced activity of MMP-2 in I/R hearts was reversed in hearts subjected to LF-EMF. The data presented here indicate that acute exposure to LF-EMF protects mechanical function of I/R hearts and reduces I/R injury.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationIsolated rat hearts (ex vivo)
Sample sizeNot supplied
ExposureELF · acute; during 20 min ischemia and 30 min reperfusion (isolated rat heart I/R protocol)
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In isolated rat hearts subjected to ischemia/reperfusion, LF-EMF exposure prevented a decrease in rate pressure product and increased LVDP, with no effect on coronary flow. Elevated TnI and IL-6 in I/R hearts returned to baseline levels with LF-EMF, and reduced MMP-2 activity in I/R hearts was reversed by LF-EMF.

Outcomes measured

  • Heart mechanical function (coronary flow, heart rate, left ventricular developed pressure (LVDP), rate pressure product (RPP))
  • Markers of heart injury (troponin I (TnI), interleukin-6 (IL-6))
  • Cardiac matrix metalloproteinase-2 (MMP-2) activity

Limitations

  • Frequency and field strength/dose parameters of LF-EMF not reported in the abstract
  • Ex vivo isolated rat heart model; generalizability to in vivo or humans not addressed in the abstract
  • Sample size not provided in the abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "acute; during 20 min ischemia and 30 min reperfusion (isolated rat heart I/R protocol)"
  },
  "population": "Isolated rat hearts (ex vivo)",
  "sample_size": null,
  "outcomes": [
    "Heart mechanical function (coronary flow, heart rate, left ventricular developed pressure (LVDP), rate pressure product (RPP))",
    "Markers of heart injury (troponin I (TnI), interleukin-6 (IL-6))",
    "Cardiac matrix metalloproteinase-2 (MMP-2) activity"
  ],
  "main_findings": "In isolated rat hearts subjected to ischemia/reperfusion, LF-EMF exposure prevented a decrease in rate pressure product and increased LVDP, with no effect on coronary flow. Elevated TnI and IL-6 in I/R hearts returned to baseline levels with LF-EMF, and reduced MMP-2 activity in I/R hearts was reversed by LF-EMF.",
  "effect_direction": "benefit",
  "limitations": [
    "Frequency and field strength/dose parameters of LF-EMF not reported in the abstract",
    "Ex vivo isolated rat heart model; generalizability to in vivo or humans not addressed in the abstract",
    "Sample size not provided in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "low frequency electromagnetic field",
    "LF-EMF",
    "ELF",
    "ischemia/reperfusion",
    "isolated rat heart",
    "contractile dysfunction",
    "reactive oxygen species",
    "troponin I",
    "interleukin-6",
    "MMP-2",
    "rate pressure product",
    "left ventricular developed pressure"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1155/2015/396593
PubMed: 25961016

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