Magnetic resonance imaging of hepatocellular carcinoma in Long-Evans cinnamon rats under a magnetic field of 7.05 T.

The Japanese journal of veterinary research · 1997 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 4151

Study snapshot

PublicationThe Japanese journal of veterinary research · 1997

Study typeanimal

Reported directionUnclear

Evidence ratingInsufficient

Abstract

Magnetic resonance (MR) images of livers in 3-, 12- and 29-month-old Long-Evans Cinnamon(LEC) rats (male) were taken under a magnetic field of 7.05 T. MR images of sagittal and transversal sections were obtained in 1-mm-thick slices by T1-weighted and two-dimensional Fourier transformation techniques. The data matrix size was 256 phase-encoded steps. Each image was obtained through four acquisitions. Three-month-old rats gave MR images with low signal intensity over the liver probably due to the shorting of its T1 and T2 relaxation times. However, 12-month-old rats gave hyperintense regions around hepatic veins in right hepatic lobe, which was assigned to hepatocellular carcinoma. In 29-month-old rats, MR images with hyperintensity throughout the hepatic lobe were observed. These MR images, therefore, suggested that hepatocellular carcinoma in LEC rats developed from the restricted regions surrounding hepatic veins. In the present study, T1-weighted MR imaging under a magnetic field of 7.05 T was shown to be applicable to the diagnosis of hepatic cancer in LEC rats.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionunclear

PopulationMale Long-Evans Cinnamon (LEC) rats aged 3, 12, and 29 months

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

T1-weighted MR images acquired under a 7.05 T magnetic field showed age-related liver signal patterns in LEC rats: low signal intensity at 3 months, hyperintense regions around hepatic veins at 12 months (assigned to hepatocellular carcinoma), and hyperintensity throughout the hepatic lobe at 29 months. The imaging findings suggested HCC developed from restricted regions surrounding hepatic veins and that 7.05 T T1-weighted MRI was applicable for diagnosing hepatic cancer in this rat model.

Outcomes measured

MRI liver signal intensity patterns on T1-weighted images
Detection/diagnosis of hepatocellular carcinoma (HCC) location and extent

Limitations

Sample size not reported in the abstract
No quantitative exposure metrics beyond magnetic field strength (e.g., scan time, RF parameters, SAR)
Primarily an imaging/diagnostic study; does not assess health effects attributable to magnetic field exposure

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "magnetic resonance imaging (MRI) static magnetic field",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Male Long-Evans Cinnamon (LEC) rats aged 3, 12, and 29 months",
  "sample_size": null,
  "outcomes": [
    "MRI liver signal intensity patterns on T1-weighted images",
    "Detection/diagnosis of hepatocellular carcinoma (HCC) location and extent"
  ],
  "main_findings": "T1-weighted MR images acquired under a 7.05 T magnetic field showed age-related liver signal patterns in LEC rats: low signal intensity at 3 months, hyperintense regions around hepatic veins at 12 months (assigned to hepatocellular carcinoma), and hyperintensity throughout the hepatic lobe at 29 months. The imaging findings suggested HCC developed from restricted regions surrounding hepatic veins and that 7.05 T T1-weighted MRI was applicable for diagnosing hepatic cancer in this rat model.",
  "effect_direction": "unclear",
  "limitations": [
    "Sample size not reported in the abstract",
    "No quantitative exposure metrics beyond magnetic field strength (e.g., scan time, RF parameters, SAR)",
    "Primarily an imaging/diagnostic study; does not assess health effects attributable to magnetic field exposure"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "MRI",
    "7.05 T",
    "static magnetic field",
    "T1-weighted imaging",
    "Long-Evans Cinnamon rats",
    "hepatocellular carcinoma",
    "liver imaging"
  ],
  "suggested_hubs": [
    {
      "slug": "mri-static-fields",
      "weight": 0.9,
      "reason": "Study involves MRI performed under a 7.05 T magnetic field in an animal model."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 9433015

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