Electrophysiological modeling study of ECG T-wave alternation caused by ultrahigh static magnetic fields.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2005 · Harm · Very low evidence

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HarmVery low evidencePaper 3588

Study snapshot

PublicationConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2005

Study typeother

Reported directionHarm

Evidence ratingVery low

Abstract

The goal of our research is try to explain the electrophysiological mechanisms of alternation in T-wave of ECG in ultrahigh static magnetic field (SMF). The magneto-hydrodynamics model study shows that ultrahigh SMF can induce reduction in the volume flow rate of the blood in human arota more than 10%, thus may lead to anoxia condition of acute ischemia. Using an ionic-based theoretical model of the cardiac ventricular cell, we simulate transmural heterogeneous suppression of the action potential plateau and action potential duration shortening in case of different anoxia degree. The results demonstrated that anoxia may produce a significant increase in the T-wave amplitude, which may be another mechanism for the influence of ultrahigh SMF to T-wave. This finding is consistent with experimental observation. This study suggests that one should strengthen the safety inspection of ECG in MRI scan and in other application of ultrahigh SMF.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionharm

PopulationNot supplied

Sample sizeNot supplied

Exposurestatic

Evidence strengthVery lowConfidence: 66% · Peer reviewed: yes

Main findings

A magneto-hydrodynamics model suggested that ultrahigh static magnetic fields could reduce blood volume flow rate in the human aorta by more than 10%, which the authors propose may lead to an anoxia condition of acute ischemia. Using an ionic-based ventricular cell model, simulations indicated that anoxia could increase T-wave amplitude and was presented as a possible mechanism contributing to T-wave effects observed under ultrahigh static magnetic fields.

Outcomes measured

ECG T-wave alternation
T-wave amplitude
blood volume flow rate in aorta
anoxia/acute ischemia (modeled)
ventricular action potential plateau suppression
action potential duration shortening

Limitations

Modeling study (magneto-hydrodynamics and theoretical ionic-based cell simulations) rather than direct human or animal exposure measurements
Exposure level described as 'ultrahigh' static magnetic field without quantitative field strength in the abstract
Causal pathway (SMF → reduced flow → anoxia → ECG changes) is proposed based on simulations; empirical confirmation details not provided in the abstract

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": "static",
    "source": "MRI",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "ECG T-wave alternation",
    "T-wave amplitude",
    "blood volume flow rate in aorta",
    "anoxia/acute ischemia (modeled)",
    "ventricular action potential plateau suppression",
    "action potential duration shortening"
  ],
  "main_findings": "A magneto-hydrodynamics model suggested that ultrahigh static magnetic fields could reduce blood volume flow rate in the human aorta by more than 10%, which the authors propose may lead to an anoxia condition of acute ischemia. Using an ionic-based ventricular cell model, simulations indicated that anoxia could increase T-wave amplitude and was presented as a possible mechanism contributing to T-wave effects observed under ultrahigh static magnetic fields.",
  "effect_direction": "harm",
  "limitations": [
    "Modeling study (magneto-hydrodynamics and theoretical ionic-based cell simulations) rather than direct human or animal exposure measurements",
    "Exposure level described as 'ultrahigh' static magnetic field without quantitative field strength in the abstract",
    "Causal pathway (SMF → reduced flow → anoxia → ECG changes) is proposed based on simulations; empirical confirmation details not provided in the abstract"
  ],
  "evidence_strength": "very_low",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "ultrahigh SMF",
    "MRI",
    "ECG",
    "T-wave alternation",
    "T-wave amplitude",
    "magneto-hydrodynamics",
    "aorta blood flow",
    "anoxia",
    "ischemia",
    "ventricular cell model",
    "action potential duration"
  ],
  "suggested_hubs": [
    {
      "slug": "mri-static-fields",
      "weight": 0.9,
      "reason": "Focuses on ultrahigh static magnetic fields with explicit mention of MRI scanning and ECG safety inspection."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/iembs.2005.1617108
PubMed: 17282877

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