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[The influence of pulsed magnetic fields on SOD's activity and MDA value in metabolism of mice].

Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 1999 · Mixed · Low evidence

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MixedLow evidencePaper 4008

Thirty-two mice were exposed to 20 Hz pulsed magnetic fields at 0 T (control), 0.25 T, 0.34 T, or 0.64 T for 40 minutes. SOD activity and MDA were significantly lower in the 0.34 T group than in controls, while the 0.25 T and 0.64 T groups did not differ sign…

Study snapshot

PublicationSheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 1999
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

This experiment aimed to investigate the influence of pulsed extremely-low-frequency-magnetic fields on free radical metabolism of mice. Thirty-two mice were randomly divided into four groups and were exposed to 0 T, 0.25 T, 0.34 T and 0.64 T intensity pulsed magnetic fields of 20 Hz for 40 min. The 0 T exposed group was the control group. The free radical metabolism, SOD's activity and MDA, of mice were measured respectively. The result showed the SOD's activity and MDA of the 0.34 T exposed group were both significantly lower (P < 0.01, P < 0.05) than that of the control group, while the 0.25 T and 0.64 T exposed groups were not significantly different from the control group. This demonstrates that the biological effect of pulsed extremely-low-frequency magnetic fields on free radical metabolism of mice varies and depends on the intensity of the fields. The "window" effect may exist.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
Populationmice
Sample size32
ExposureELF · 40 min
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Thirty-two mice were exposed to 20 Hz pulsed magnetic fields at 0 T (control), 0.25 T, 0.34 T, or 0.64 T for 40 minutes. SOD activity and MDA were significantly lower in the 0.34 T group than in controls, while the 0.25 T and 0.64 T groups did not differ significantly from controls.

Outcomes measured

  • SOD activity
  • MDA value
  • free radical metabolism

Limitations

  • Only one exposure duration reported (40 min)
  • Findings differed by field intensity (only 0.34 T showed significant changes)
  • No additional methodological details provided in abstract (e.g., blinding, timing of outcome measurement)
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "pulsed magnetic fields",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "40 min"
  },
  "population": "mice",
  "sample_size": 32,
  "outcomes": [
    "SOD activity",
    "MDA value",
    "free radical metabolism"
  ],
  "main_findings": "Thirty-two mice were exposed to 20 Hz pulsed magnetic fields at 0 T (control), 0.25 T, 0.34 T, or 0.64 T for 40 minutes. SOD activity and MDA were significantly lower in the 0.34 T group than in controls, while the 0.25 T and 0.64 T groups did not differ significantly from controls.",
  "effect_direction": "mixed",
  "limitations": [
    "Only one exposure duration reported (40 min)",
    "Findings differed by field intensity (only 0.34 T showed significant changes)",
    "No additional methodological details provided in abstract (e.g., blinding, timing of outcome measurement)"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "pulsed magnetic fields",
    "extremely low frequency",
    "20 Hz",
    "mice",
    "SOD",
    "superoxide dismutase",
    "MDA",
    "malondialdehyde",
    "free radicals",
    "window effect"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.2,
      "reason": "Uses relatively high-intensity ELF magnetic fields; could be relevant to high-field exposure contexts, though no occupational setting is stated."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 12552762

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