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[The effect of microwave radiation on the levels of MDA and the activity of SOD of nasopharyngeal carcinoma cells].

Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2008 · Harm · Low evidence

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HarmLow evidencePaper 6474

Compared with control, MDA levels increased with higher microwave radiation intensity (reported as 1.4× at 20 mW/cm2 and 3.5× at 30 mW/cm2; P<0.05). SOD activity decreased with increasing intensity (reported as 68.2%, 46.2%, and 36.0% of control at 10, 20, an…

Study snapshot

PublicationLin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2008
Study typein_vitro
Reported directionHarm
Evidence ratingLow

Abstract

OBJECTIVE: To study the effect of microwave radiation on the levels of malondialdehyde (MDIA) and activity of superoxide dismutase (SOD) of Nasopharyngeal carcinoma cells. METHOD: The experiment were divided into four groups included control, 10, 20 and 30 mW/cm2 groups. The methods, such as TBA colorimetric assay and modified NBT hydroxylamine method, were used to detect the effect of microwave radiation on the levels of MDA and activity of SOD of nasopharyngeal carcinoma cells. RESULT: With increase of microwave radiation, TBA assay showed that the levels of MAD were 1.4 and 3.5 times in 20 mW/cm2 group and 30 mW/cm2 group respectively compared with control group, there were significant differences among them (P < 0.05). NBT method shows that the activity of SOD were 68.2%, 46.2% and 36.0% of 10, 20 and 30 mW/cm2 groups respectively compared with control group, there were significant differences among them too (P < 0.01). CONCLUSION: Microwave Radiation could up-regulate the levels of MAD) while down-regulate the SOD activity.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionharm
PopulationNasopharyngeal carcinoma cells
Sample sizeNot supplied
Exposuremicrowave
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Compared with control, MDA levels increased with higher microwave radiation intensity (reported as 1.4× at 20 mW/cm2 and 3.5× at 30 mW/cm2; P<0.05). SOD activity decreased with increasing intensity (reported as 68.2%, 46.2%, and 36.0% of control at 10, 20, and 30 mW/cm2, respectively; P<0.01).

Outcomes measured

  • Malondialdehyde (MDA) levels
  • Superoxide dismutase (SOD) activity

Limitations

  • Microwave frequency not reported.
  • Exposure duration not reported.
  • Sample size not reported.
  • In vitro study in carcinoma cells; generalizability to humans not established in abstract.
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Nasopharyngeal carcinoma cells",
  "sample_size": null,
  "outcomes": [
    "Malondialdehyde (MDA) levels",
    "Superoxide dismutase (SOD) activity"
  ],
  "main_findings": "Compared with control, MDA levels increased with higher microwave radiation intensity (reported as 1.4× at 20 mW/cm2 and 3.5× at 30 mW/cm2; P<0.05). SOD activity decreased with increasing intensity (reported as 68.2%, 46.2%, and 36.0% of control at 10, 20, and 30 mW/cm2, respectively; P<0.01).",
  "effect_direction": "harm",
  "limitations": [
    "Microwave frequency not reported.",
    "Exposure duration not reported.",
    "Sample size not reported.",
    "In vitro study in carcinoma cells; generalizability to humans not established in abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "malondialdehyde",
    "MDA",
    "superoxide dismutase",
    "SOD",
    "oxidative stress",
    "nasopharyngeal carcinoma",
    "cell study"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 18476619

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