Effects of long-term exposure to an extremely low frequency magnetic field (15 µT) on selected blood coagulation variables in OF1 mice

2019 · Mixed · Low evidence

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MixedLow evidencePaper 1762

In the studied coagulation variables, differences were largely attributed to sex. In females, ELF-MF exposure was associated with a very significant shortening of PT, significant increases in APTT and RT, and an overall reduction in sex differences.

Study snapshot

Publicationmanual · 2019

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Effects of long-term exposure to an extremely low frequency magnetic field (15 µT) on selected blood coagulation variables in OF1 mice Vallejo D, Hidalgo MA, Hernández JM. Effects of long-term exposure to an extremely low frequency magnetic field (15 µT) on selected blood coagulation variables in OF1 mice. Electromagn Biol Med. 2019 Jul 13:1-8. doi: 10.1080/15368378.2019.1641719. Abstract The long-term exposure of OF1 mice to an extremely low frequency magnetic field (ELF-MF; 50 Hz, 15 µT [rms]) has been associated with the appearance of leukaemia. Neoplasms are usually accompanied by changes in haemostatic processes but reports on changes in blood coagulation following exposure to an ELF-MF are scarce and rather fragmentary. The aim of the present work was to determine whether any global or partial coagulation variables are modified after such long-term exposure. A parental generation of six week-old OF1 mice was exposed to an artificial ELF-MF for 14 weeks. Mating was then allowed, and the resulting filial generation raised until the age of 31-35 weeks within the same ELF-MF. Control animals were subjected only to the magnetic field of the Earth. Whole blood samples were extracted from the anesthetised filial generation of mice by cardiac puncture. White blood cells (WBC) were counted, the activated partial thromboplastin time (APTT) and prothrombin time (PT) determined, and plasma fibrinogen, reptilase time (RT), and factor VIII activity examined. The similarity between the results for the present control animals and those recorded in the literature for human blood render OF1 mice a suitable study model. The differences in the studied coagulation variables were largely owed simply to sex. However, the females showed a very significant shortening of the PT time associated with ELF-MF exposure. Exposure also caused significant increases in the female APTT and RT values, and in general reduced the differences between the sexes. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationOF1 mice (parental generation exposed; outcomes measured in filial generation at 31–35 weeks)

Sample sizeNot supplied

ExposureELF · Parental generation exposed for 14 weeks; filial generation raised to age 31–35 weeks within the same ELF-MF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

White blood cell (WBC) count
Activated partial thromboplastin time (APTT)
Prothrombin time (PT)
Plasma fibrinogen
Reptilase time (RT)
Factor VIII activity

Limitations

Sample size not reported in the provided abstract/metadata
Only selected coagulation variables were assessed
Findings reported primarily for females; effects in males not clearly described in the abstract
Animal model; generalizability to humans not established in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "artificial magnetic field",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "Parental generation exposed for 14 weeks; filial generation raised to age 31–35 weeks within the same ELF-MF"
  },
  "population": "OF1 mice (parental generation exposed; outcomes measured in filial generation at 31–35 weeks)",
  "sample_size": null,
  "outcomes": [
    "White blood cell (WBC) count",
    "Activated partial thromboplastin time (APTT)",
    "Prothrombin time (PT)",
    "Plasma fibrinogen",
    "Reptilase time (RT)",
    "Factor VIII activity"
  ],
  "main_findings": "In the studied coagulation variables, differences were largely attributed to sex. In females, ELF-MF exposure was associated with a very significant shortening of PT, significant increases in APTT and RT, and an overall reduction in sex differences.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in the provided abstract/metadata",
    "Only selected coagulation variables were assessed",
    "Findings reported primarily for females; effects in males not clearly described in the abstract",
    "Animal model; generalizability to humans not established in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low frequency",
    "ELF-MF",
    "50 Hz",
    "15 µT",
    "mice",
    "OF1",
    "blood coagulation",
    "haemostasis",
    "prothrombin time",
    "activated partial thromboplastin time",
    "reptilase time",
    "fibrinogen",
    "factor VIII"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.2,
      "reason": "Study involves controlled long-term ELF magnetic field exposure (50 Hz), which can be relevant to ELF exposure contexts, though no workplace setting is specified."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/15368378.2019.1641719
PubMed: Not supplied

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