RF Safe

Therapeutic electromagnetic field effects on angiogenesis and tumor growth.

Anticancer research · 2001 · Benefit · Low evidence

← Research stream
BenefitLow evidencePaper 3887

Compared with controls, exposure to therapeutic electromagnetic fields significantly reduced tumor growth and reduced CD31-stained area (interpreted as reduced vascularization), with a concomitant increase in tumor necrosis.

Study snapshot

PublicationAnticancer research · 2001
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

BACKGROUND: A new approach to cancer therapy based on the application of therapeutic electromagnetic fields (TEMF) has been developed by EMF Therapeutics, Inc., Chattanooga, TN, USA. This study was designed to assess the effect of TEMF on tumor vascularization and growth of murine 16/C mammary adenocarcinoma cells in C3H/HeJ mice. MATERIALS AND METHODS: Implanted tumors were allowed to grow for seven days until the tumor volume reached 100 mm3 before treatment was started. Mice (20 per control, 10 per EMF exposed group) received treatment (10 minutes per day with 0, 10 mT, 15 mT or 20 mT) with a 120 pulses per second pulsating magnetic field. Tumor growth was assessed throughout the treatment period. The extent of tumor vascularization was evaluated by immunohistochemical staining for CD31. RESULTS: Exposure to TEMF significantly reduced tumor growth, significantly reduced the percentage of area stained for CD31 indicating a reduction in the extent of vascularization and there was a concomitant increase in the extent of tumor necrosis. CONCLUSION: A novel TEMF treatment safely reduced growth and vascularization of implanted breast cancers in mice. IMPLICATION: TEMF may prove a useful adjuvant to increase the therapeutic index of conventional cancer therapy.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationC3H/HeJ mice with implanted murine 16/C mammary adenocarcinoma tumors
Sample size30
Exposure10 minutes per day
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Compared with controls, exposure to therapeutic electromagnetic fields significantly reduced tumor growth and reduced CD31-stained area (interpreted as reduced vascularization), with a concomitant increase in tumor necrosis.

Outcomes measured

  • tumor growth
  • tumor vascularization (CD31 immunohistochemical staining)
  • tumor necrosis

Limitations

  • Frequency characteristics beyond '120 pulses per second' not described in abstract
  • Exposure metric reported in mT without additional dosimetry details
  • Group sizes unequal (20 control vs 10 exposed) and allocation details not described in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "therapeutic electromagnetic fields (pulsating magnetic field)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "10 minutes per day"
  },
  "population": "C3H/HeJ mice with implanted murine 16/C mammary adenocarcinoma tumors",
  "sample_size": 30,
  "outcomes": [
    "tumor growth",
    "tumor vascularization (CD31 immunohistochemical staining)",
    "tumor necrosis"
  ],
  "main_findings": "Compared with controls, exposure to therapeutic electromagnetic fields significantly reduced tumor growth and reduced CD31-stained area (interpreted as reduced vascularization), with a concomitant increase in tumor necrosis.",
  "effect_direction": "benefit",
  "limitations": [
    "Frequency characteristics beyond '120 pulses per second' not described in abstract",
    "Exposure metric reported in mT without additional dosimetry details",
    "Group sizes unequal (20 control vs 10 exposed) and allocation details not described in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "therapeutic electromagnetic fields",
    "pulsating magnetic field",
    "angiogenesis",
    "tumor vascularization",
    "CD31",
    "mammary adenocarcinoma",
    "mouse model",
    "tumor growth",
    "necrosis",
    "millitesla"
  ],
  "suggested_hubs": []
}
AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 11911264

Read the original paper →

Related papers

← Back to the Research Library