The Effect of Pulsed Electromagnetic Fields on Angiogenesis

Bioelectromagnetics · 2021 · Benefit · Low evidence

← Research stream

BenefitLow evidencePaper 1196

Study snapshot

PublicationBioelectromagnetics · 2021

Study typereview

Reported directionBenefit

Evidence ratingLow

Abstract

The Effect of Pulsed Electromagnetic Fields on Angiogenesis Lihong Peng, Chenying Fu, Lu Wang, Qing Zhang, Zejun Liang, Chengqi He, Quan Wei. The Effect of Pulsed Electromagnetic Fields on Angiogenesis. Bioelectromagnetics. 2021 Mar 6. doi: 10.1002/bem.22330. Abstract A pulsed electromagnetic field (PEMF) has been used to treat inflammation-based diseases such as osteoporosis, neurological injury, and osteoarthritis. Numerous animal experiments and in vitro studies have shown that PEMF may affect angiogenesis. For ischemic diseases, in theory, blood flow may be richer by increasing the number of blood vessels which supply blood to ischemic tissue. PEMF plays a role in enhancing angiogenesis, and their clinical application may go far beyond the current scope. In this review, we analyzed and summarized the effects and possible mechanisms of PEMF on angiogenesis. Most studies have shown that PEMF with specific parameters can promote angiogenesis, which is manifested by an increased vascular growth rate and increased capillary density. The potential mechanisms consist of promoting vascular endothelial cell proliferation, migration, and tube formation, and increasing the expression level of vascular endothelial growth factor (VEGF), fibroblast growth factor 2 (FGF2), angiopoietin-2 (Ang-2), and other angiogenic growth factors. Additionally, PEMF has an impact on the activation of voltage-gated calcium channels (VGCC). pubmed.ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typereview

Effect directionbenefit

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

This review summarizes animal and in vitro evidence on pulsed electromagnetic fields (PEMF) and angiogenesis. The abstract states that most studies report PEMF with specific parameters can promote angiogenesis, reflected by increased vascular growth rate and capillary density, potentially via effects on endothelial cell functions and increased expression of angiogenic factors (e.g., VEGF, FGF2, Ang-2) and impacts on VGCC activation.

Outcomes measured

Angiogenesis
Vascular growth rate
Capillary density
Endothelial cell proliferation
Endothelial cell migration
Tube formation
Expression of VEGF
Expression of FGF2
Expression of Ang-2
Activation of voltage-gated calcium channels (VGCC)

Limitations

Review article; no specific PEMF parameters (e.g., frequency/intensity) are provided in the abstract.
Evidence described includes animal experiments and in vitro studies; human clinical evidence is not detailed in the abstract.
The abstract does not describe search strategy, inclusion criteria, or risk-of-bias assessment.

View raw extracted JSON

{
  "study_type": "review",
  "exposure": {
    "band": null,
    "source": "pulsed electromagnetic field (PEMF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Angiogenesis",
    "Vascular growth rate",
    "Capillary density",
    "Endothelial cell proliferation",
    "Endothelial cell migration",
    "Tube formation",
    "Expression of VEGF",
    "Expression of FGF2",
    "Expression of Ang-2",
    "Activation of voltage-gated calcium channels (VGCC)"
  ],
  "main_findings": "This review summarizes animal and in vitro evidence on pulsed electromagnetic fields (PEMF) and angiogenesis. The abstract states that most studies report PEMF with specific parameters can promote angiogenesis, reflected by increased vascular growth rate and capillary density, potentially via effects on endothelial cell functions and increased expression of angiogenic factors (e.g., VEGF, FGF2, Ang-2) and impacts on VGCC activation.",
  "effect_direction": "benefit",
  "limitations": [
    "Review article; no specific PEMF parameters (e.g., frequency/intensity) are provided in the abstract.",
    "Evidence described includes animal experiments and in vitro studies; human clinical evidence is not detailed in the abstract.",
    "The abstract does not describe search strategy, inclusion criteria, or risk-of-bias assessment."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "pulsed electromagnetic field",
    "PEMF",
    "angiogenesis",
    "ischemic diseases",
    "capillary density",
    "vascular growth",
    "endothelial cells",
    "VEGF",
    "FGF2",
    "Ang-2",
    "voltage-gated calcium channels",
    "VGCC"
  ],
  "suggested_hubs": []
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.22330
PubMed: 33675261

Read the original paper →

Related papers

← Back to the Research Library