Effect of cell-phone RF on angiogenesis and cell invasion in human head and neck cancer cells

2018 · Harm · Low evidence

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HarmLow evidencePaper 2079

In CAM and human head and neck cancer cell line models (FaDu, SCC25), cell-phone radiofrequency exposure promoted angiogenesis, increased cell invasion and colony formation, downregulated E-cadherin expression, and activated Erk1/Erk2.

Study snapshot

Publicationmanual · 2018

Study typein_vitro

Reported directionHarm

Evidence ratingLow

Abstract

Effect of cell-phone RF on angiogenesis and cell invasion in human head and neck cancer cells Alahmad YM, Aljaber M, Saleh AI, Yalcin HC, Aboulkassim T, Yasmeen A, Batist G, Moustafa AA. Effect of cell- phone radiofrequency on angiogenesis and cell invasion in human head and neck cancer cells. Head Neck. 2018 May 13. doi: 10.1002/hed.25210. Abstract BACKGROUND: Today, the cell phone is the most widespread technology globally. However, the outcome of cell-phone radiofrequency on head and neck cancer progression has not yet been explored. METHODS: The chorioallantoic membrane (CAM) and human head and neck cancer cell lines, FaDu and SCC25, were used to explore the outcome of cell-phone radiofrequency on angiogenesis, cell invasion, and colony formation of head and neck cancer cells, respectively. Western blot analysis was used to investigate the impact of the cell phone on the regulation of E-cadherin and Erk1/Erk2 genes. RESULTS: Our data revealed that cell-phone radiofrequency promotes angiogenesis of the CAM. In addition, the cell phone enhances cell invasion and colony formation of human head and neck cancer cells; this is accompanied by a downregulation of E-cadherin expression. More significantly, we found that the cell phone can activate Erk1/Erk2 in our experimental models. CONCLUSION: Our investigation reveals that cell-phone radiofrequency could enhance head and neck cancer by stimulating angiogenesis and cell invasion via Erk1/Erk2 activation. ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationNot supplied

Sample sizeNot supplied

ExposureRF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

angiogenesis (CAM assay)
cell invasion
colony formation
E-cadherin expression
Erk1/Erk2 activation

Limitations

Exposure parameters (eg, frequency, SAR, duration) not reported in provided abstract
Sample size not reported in provided abstract
Models include CAM and cancer cell lines; findings may not generalize to humans

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "angiogenesis (CAM assay)",
    "cell invasion",
    "colony formation",
    "E-cadherin expression",
    "Erk1/Erk2 activation"
  ],
  "main_findings": "In CAM and human head and neck cancer cell line models (FaDu, SCC25), cell-phone radiofrequency exposure promoted angiogenesis, increased cell invasion and colony formation, downregulated E-cadherin expression, and activated Erk1/Erk2.",
  "effect_direction": "harm",
  "limitations": [
    "Exposure parameters (eg, frequency, SAR, duration) not reported in provided abstract",
    "Sample size not reported in provided abstract",
    "Models include CAM and cancer cell lines; findings may not generalize to humans"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "cell phone",
    "radiofrequency",
    "RF",
    "angiogenesis",
    "cell invasion",
    "colony formation",
    "head and neck cancer",
    "FaDu",
    "SCC25",
    "CAM",
    "E-cadherin",
    "Erk1/Erk2"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones-rf",
      "weight": 0.9,
      "reason": "Study examines effects of cell-phone radiofrequency exposure."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/hed.25210
PubMed: Not supplied

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