Vascular effect and immunity effect of steep pulse electric field on Walker 256-bearing Wistar mice.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2004 · Benefit · Low evidence

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BenefitLow evidencePaper 3616

Study snapshot

PublicationConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2004

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

The vascular effect and immunity effect of SPEF on Wistar mice were studied, and the possible treatment mechanisms and clinical trial methods of SPEF were discussed. We tested lymphocyte proliferation ratio and activity of NK cell, and the contents of IFN-alpha and IL-4 in the serum lymphocyte were inspected with ELISA method. Moreover, macrophage were collected, the content of TNF-alpha excreted by macrophage were inspected with ELISA method, too. Statistical analysis was performed using the SPSS10.0 software package and t-test. VEGF level in test group was significantly decreased, and VEGF expression was weakened evidently. SPEF strengthened activity of NK cell, enlarged quantities of TNF-alpha from test group, accelerated exudation of TH1 cell factor and slowed exudation of TH2 cell factor. SPEF showed effective anti-tumor effect through restraining the formation of fresh vessels and baffling the birth and transfer of tumor cell. It could strengthen organism immunity function, and had visible effect on Walker-256 tumor.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationWalker 256-bearing Wistar mice

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthLowConfidence: 74% · Peer reviewed: unknown

Main findings

In the test group, VEGF level was significantly decreased and VEGF expression was evidently weakened. SPEF increased NK cell activity, increased TNF-alpha from macrophages, accelerated exudation of TH1 cell factor and slowed exudation of TH2 cell factor. The authors report an effective anti-tumor effect on Walker-256 tumor, attributed to restraining new vessel formation and inhibiting tumor cell development/transfer, alongside strengthened immunity function.

Outcomes measured

VEGF level/expression
NK cell activity
lymphocyte proliferation ratio
serum IFN-alpha
serum IL-4
macrophage TNF-alpha secretion
TH1/TH2 factor exudation
anti-tumor effect (Walker-256 tumor)
tumor angiogenesis/new vessel formation

Limitations

No exposure parameters reported (e.g., field strength, pulse characteristics, duration).
Sample size not reported in the abstract.
Outcomes and tumor effects are described without quantitative effect sizes in the abstract.
Conference proceedings context; details of design (randomization/blinding/control conditions) not described in the abstract.

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "steep pulse electric field (SPEF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Walker 256-bearing Wistar mice",
  "sample_size": null,
  "outcomes": [
    "VEGF level/expression",
    "NK cell activity",
    "lymphocyte proliferation ratio",
    "serum IFN-alpha",
    "serum IL-4",
    "macrophage TNF-alpha secretion",
    "TH1/TH2 factor exudation",
    "anti-tumor effect (Walker-256 tumor)",
    "tumor angiogenesis/new vessel formation"
  ],
  "main_findings": "In the test group, VEGF level was significantly decreased and VEGF expression was evidently weakened. SPEF increased NK cell activity, increased TNF-alpha from macrophages, accelerated exudation of TH1 cell factor and slowed exudation of TH2 cell factor. The authors report an effective anti-tumor effect on Walker-256 tumor, attributed to restraining new vessel formation and inhibiting tumor cell development/transfer, alongside strengthened immunity function.",
  "effect_direction": "benefit",
  "limitations": [
    "No exposure parameters reported (e.g., field strength, pulse characteristics, duration).",
    "Sample size not reported in the abstract.",
    "Outcomes and tumor effects are described without quantitative effect sizes in the abstract.",
    "Conference proceedings context; details of design (randomization/blinding/control conditions) not described in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "steep pulse electric field",
    "SPEF",
    "Walker 256",
    "Wistar mice",
    "VEGF",
    "angiogenesis",
    "NK cell",
    "TNF-alpha",
    "IFN-alpha",
    "IL-4",
    "TH1",
    "TH2",
    "anti-tumor"
  ],
  "suggested_hubs": [
    {
      "slug": "animal-studies",
      "weight": 0.78,
      "reason": "Study conducted in Walker 256-bearing Wistar mice assessing vascular and immune effects of an electric field intervention."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/iembs.2004.1404384
PubMed: 17271440

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