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Lethal and inhibitory effects of steep pulsed electric field on tumor-bearing BALB/c mice.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2004 · Benefit · Low evidence

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BenefitLow evidencePaper 3617

In tumor-bearing BALB/c mice, SPEF treatment was reported to irreversibly damage tumor cells on histological and ultrastructural observation. Tumor volume measurements indicated SPEF significantly slowed tumor growth. Average survival time was 33.03 days in c…

Study snapshot

PublicationConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2004
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

Exposing cancer cell to steep pulsed electric field (SPEF) with appropriate dosage, the cell may die due to irreversible electrical breakdown (IREB). 48 BALB/c mice inoculated with U/sub 14/ cervical cancer cell were treated with SPEF to study the lethal and inhibitory effects of SPEF on them. They were randomly divided into test group (26) and control group (22), and then four experiments were carried out. Histological observation and ultrastructural observation showed that SPEF destroyed the integrality of tumor cell irreversibly with pyknosis, karyoclasis and karyolysis. Tumor volume measurement indicated that SPEF significantly slowed down the growth speed of tumor. In the experiment of survival time investigation, the average survival time of control group and test group was 33.03 days and no less than 52.05 days respectively, which confirmed that SPEF prolonged the survival time of tumor-bearing mice obviously. With further experimental study and mechanism analysis, this technique is quite possible to be an effective physiotherapy for tumor treatment.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationTumor-bearing BALB/c mice inoculated with U14 cervical cancer cells
Sample size48
ExposureNot supplied
Evidence strengthLowConfidence: 74% · Peer reviewed: unknown

Main findings

In tumor-bearing BALB/c mice, SPEF treatment was reported to irreversibly damage tumor cells on histological and ultrastructural observation. Tumor volume measurements indicated SPEF significantly slowed tumor growth. Average survival time was 33.03 days in controls versus no less than 52.05 days in the SPEF-treated group.

Outcomes measured

  • Tumor cell histology/ultrastructure (pyknosis, karyoclasis, karyolysis)
  • Tumor volume/growth rate
  • Survival time

Limitations

  • Exposure parameters/dosage details not provided in the abstract (e.g., field strength, pulse characteristics, treatment schedule).
  • No quantitative tumor volume results reported in the abstract beyond 'significantly slowed'.
  • Blinding and randomization procedures not described beyond group assignment.
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "steep pulsed electric field (SPEF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Tumor-bearing BALB/c mice inoculated with U14 cervical cancer cells",
  "sample_size": 48,
  "outcomes": [
    "Tumor cell histology/ultrastructure (pyknosis, karyoclasis, karyolysis)",
    "Tumor volume/growth rate",
    "Survival time"
  ],
  "main_findings": "In tumor-bearing BALB/c mice, SPEF treatment was reported to irreversibly damage tumor cells on histological and ultrastructural observation. Tumor volume measurements indicated SPEF significantly slowed tumor growth. Average survival time was 33.03 days in controls versus no less than 52.05 days in the SPEF-treated group.",
  "effect_direction": "benefit",
  "limitations": [
    "Exposure parameters/dosage details not provided in the abstract (e.g., field strength, pulse characteristics, treatment schedule).",
    "No quantitative tumor volume results reported in the abstract beyond 'significantly slowed'.",
    "Blinding and randomization procedures not described beyond group assignment."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "steep pulsed electric field",
    "SPEF",
    "irreversible electrical breakdown",
    "IREB",
    "tumor-bearing mice",
    "BALB/c",
    "U14 cervical cancer",
    "tumor growth",
    "survival time",
    "histology",
    "ultrastructure"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/iembs.2004.1404383
PubMed: 17271439

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