Cell Lysis in SWLA-2 Hybridomas due to 1 kHz AC Electric Fields.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2005 · Unclear · Insufficient evidence

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UnclearInsufficient evidencePaper 3536

The paper reports results on percentage cell lysis in SWLA-2 murine hybridomas after exposure to 1 kHz AC electric field pulses with pulse widths from 1 ms to 1 second; exposed cells were cultured and viability assessed at 48 hours.

Study snapshot

PublicationConference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference · 2005
Study typein_vitro
Reported directionUnclear
Evidence ratingInsufficient

Abstract

This paper describes results involving the percentage cell lysis of SWLA-2 murine hybridomas produced by AC electric field pulses at 1 kHz with pulse widths ranging from 1 ms to 1 second. Cells that had been exposed to the electric fields were cultured and replicate samples were examined at 48 hours to determine the number of viable cells.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionunclear
PopulationSWLA-2 murine hybridoma cells (in vitro)
Sample sizeNot supplied
ExposureELF · 0.001 MHz · pulse widths 1 ms to 1 second
Evidence strengthInsufficientConfidence: 62% · Peer reviewed: unknown

Main findings

The paper reports results on percentage cell lysis in SWLA-2 murine hybridomas after exposure to 1 kHz AC electric field pulses with pulse widths from 1 ms to 1 second; exposed cells were cultured and viability assessed at 48 hours.

Outcomes measured

  • percentage cell lysis
  • cell viability at 48 hours (number of viable cells)

Limitations

  • No exposure intensity/field strength reported in the abstract
  • No quantitative results or comparison group described in the abstract
  • Sample size and replication details not provided in the abstract
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": "other",
    "frequency_mhz": 0.001,
    "sar_wkg": null,
    "duration": "pulse widths 1 ms to 1 second"
  },
  "population": "SWLA-2 murine hybridoma cells (in vitro)",
  "sample_size": null,
  "outcomes": [
    "percentage cell lysis",
    "cell viability at 48 hours (number of viable cells)"
  ],
  "main_findings": "The paper reports results on percentage cell lysis in SWLA-2 murine hybridomas after exposure to 1 kHz AC electric field pulses with pulse widths from 1 ms to 1 second; exposed cells were cultured and viability assessed at 48 hours.",
  "effect_direction": "unclear",
  "limitations": [
    "No exposure intensity/field strength reported in the abstract",
    "No quantitative results or comparison group described in the abstract",
    "Sample size and replication details not provided in the abstract"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.62,
  "peer_reviewed_likely": "unknown",
  "keywords": [
    "AC electric field",
    "1 kHz",
    "ELF",
    "pulses",
    "cell lysis",
    "hybridoma",
    "in vitro",
    "cell viability"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.1,
      "reason": "Electric-field exposure is studied, but no specific occupational context is stated."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1109/iembs.2005.1616656
PubMed: 17282425

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