Zinc supplementation ameliorates static magnetic field-induced oxidative stress in rat tissues.

Environmental toxicology and pharmacology · 2007 · Mixed · Low evidence

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MixedLow evidencePaper 3511

Study snapshot

PublicationEnvironmental toxicology and pharmacology · 2007

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

The present study was undertaken to find out the effect of zinc supplementation on the antioxidant enzymatic system, lipid peroxidation and DNA oxidation in liver and kidney of static magnetic field (SMF) exposed rats. The exposure of rats to SMF (128mT, 1h/day during 30 consecutive days) decreased the activities of glutathione peroxidase (GPx), catalase (CAT) and the superoxide dismutase (SOD) in liver and kidney. By contrast, sub-chronic exposure to SMF increased the malondialdehyde (MDA) concentration in liver and kidney. Our results revealed an increase of the 8-oxo-7,8-dihydro-2'-desoxyguanosine (8-oxodGuo) in kidney of SMF-exposed rats. However, this biomarker of DNA oxidation remained unchanged in liver. Zinc supplementation (ZnCl(2), 40mg/l, per os) in SMF-exposed rats restored the activities of GPx, CAT and SOD in liver to those of control group. However, only CAT activity was restored in kidney. Moreover, zinc administration was able to bring down the elevated levels of MDA in the liver but not in the kidney. Interestingly, zinc supplementation attenuated DNA oxidation induced by SMF in kidney to the control level. Our investigations suggested that zinc supplementation minimizes oxidative damage induced by SMF in rat tissues.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationRats

Sample sizeNot supplied

Exposurestatic · 1 h/day for 30 consecutive days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Static magnetic field exposure (128 mT, 1 h/day for 30 days) decreased GPx, CAT, and SOD activities in liver and kidney and increased MDA in both tissues. SMF exposure increased 8-oxodGuo in kidney but not in liver. Zinc supplementation (ZnCl2, 40 mg/L, oral) in SMF-exposed rats restored liver GPx/CAT/SOD activities to control levels, restored only CAT in kidney, reduced elevated liver MDA (not kidney MDA), and attenuated kidney 8-oxodGuo to control levels.

Outcomes measured

Glutathione peroxidase (GPx) activity (liver, kidney)
Catalase (CAT) activity (liver, kidney)
Superoxide dismutase (SOD) activity (liver, kidney)
Malondialdehyde (MDA) concentration (liver, kidney)
8-oxo-7,8-dihydro-2'-desoxyguanosine (8-oxodGuo) in kidney and liver

Limitations

Sample size not reported in abstract
No details provided on randomization/blinding or control conditions in abstract
Only liver and kidney biomarkers assessed; clinical/functional outcomes not described
Zinc supplementation effects differed by tissue and biomarker

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "static",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "1 h/day for 30 consecutive days"
  },
  "population": "Rats",
  "sample_size": null,
  "outcomes": [
    "Glutathione peroxidase (GPx) activity (liver, kidney)",
    "Catalase (CAT) activity (liver, kidney)",
    "Superoxide dismutase (SOD) activity (liver, kidney)",
    "Malondialdehyde (MDA) concentration (liver, kidney)",
    "8-oxo-7,8-dihydro-2'-desoxyguanosine (8-oxodGuo) in kidney and liver"
  ],
  "main_findings": "Static magnetic field exposure (128 mT, 1 h/day for 30 days) decreased GPx, CAT, and SOD activities in liver and kidney and increased MDA in both tissues. SMF exposure increased 8-oxodGuo in kidney but not in liver. Zinc supplementation (ZnCl2, 40 mg/L, oral) in SMF-exposed rats restored liver GPx/CAT/SOD activities to control levels, restored only CAT in kidney, reduced elevated liver MDA (not kidney MDA), and attenuated kidney 8-oxodGuo to control levels.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "No details provided on randomization/blinding or control conditions in abstract",
    "Only liver and kidney biomarkers assessed; clinical/functional outcomes not described",
    "Zinc supplementation effects differed by tissue and biomarker"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "SMF",
    "128 mT",
    "oxidative stress",
    "antioxidant enzymes",
    "GPx",
    "CAT",
    "SOD",
    "lipid peroxidation",
    "MDA",
    "DNA oxidation",
    "8-oxodGuo",
    "zinc supplementation",
    "rat",
    "liver",
    "kidney"
  ],
  "suggested_hubs": [
    {
      "slug": "static-magnetic-fields",
      "weight": 0.9,
      "reason": "Animal study of health biomarkers after static magnetic field exposure (128 mT)."
    },
    {
      "slug": "oxidative-stress",
      "weight": 0.85,
      "reason": "Assesses oxidative stress markers (antioxidant enzymes, MDA, 8-oxodGuo) and modulation by zinc."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.etap.2006.09.001
PubMed: 21783757

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