Distinct fatty acid redistribution and textural changes in the brain tissue upon the static magnetic field exposure

Environmental toxicology and pharmacology · 2022 · Mixed · Low evidence

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MixedLow evidencePaper 888

Study snapshot

PublicationEnvironmental toxicology and pharmacology · 2022

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Distinct fatty acid redistribution and textural changes in the brain tissue upon the static magnetic field exposure Ilić AŽ, de Luka SR, Popović TB, Debeljak-Martačić J, Kojadinović M, Ćirković S, Ristić-Djurović JL, Trbovich AM. Distinct fatty acid redistribution and textural changes in the brain tissue upon the static magnetic field exposure. Environ Toxicol Pharmacol. 2022 Mar 19:103853. doi: 10.1016/j.etap.2022.103853. Highlights • Biochemical and imaging analysis of static magnetic field induced tissue changes. • Brain fatty acid redistribution explained and linked to the pathohistology level. • Cross-comparison of fractal, multifractal, gray level co-occurrence matrix analysis. • Subtle initial structural changes observed by the digital imaging analysis (DIA). • Combined biochemical / DIA analysis promising in the study of mild tissue changes. Abstract We observed different outcomes upon the subacute exposure to the 128 mT highly homogeneous static magnetic field (SMF) when its orientation was (i) aligned with the vertical component of the geomagnetic field; (ii) in the opposite direction. We employed the fatty acids (FA) composition and digital image analyses (DIA) to provide insights into the underlying processes and examine the possible weak SMF effects. Swiss-Webster male mice were whole-body exposed for 1h/day over five days. Brain tissue's thin liquid chromatography resulted in brain FA composition, indicating a possible sequence of changes due to the SMF exposure. Quantitative DIA accurately assessed different image parameters. Delicate textural changes were revealed in the group where pathohistological or biochemical alterations have not been detected. DIA-based biological markers seem to be very promising for studying delicate tissue changes, which results from the high sensitivity and wide availability of DIA. We observed different outcomes upon the subacute exposure to the 128 mT highly homogeneous static magnetic field (SMF) when its orientation was (i) aligned with the vertical component of the geomagnetic field; (ii) in the opposite direction. We employed the fatty acids (FA) composition and digital image analyses (DIA) to provide insights into the underlying processes and examine the possible weak SMF effects. Swiss-Webster male mice were whole-body exposed for 1h/day over five days. Brain tissue's thin liquid chromatography resulted in brain FA composition, indicating a possible sequence of changes due to the SMF exposure. Quantitative DIA accurately assessed different image parameters. Delicate textural changes were revealed in the group where pathohistological or biochemical alterations have not been detected. DIA-based biological markers seem to be very promising for studying delicate tissue changes, which results from the high sensitivity and wide availability of DIA. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationSwiss-Webster male mice

Sample sizeNot supplied

Exposurestatic · 1 h/day for five days (subacute); 128 mT highly homogeneous SMF; orientation aligned vs opposite to vertical component of geomagnetic field

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Subacute whole-body exposure to a 128 mT highly homogeneous static magnetic field produced different outcomes depending on whether the field orientation was aligned with, or opposite to, the vertical component of the geomagnetic field. Brain fatty acid composition suggested a possible sequence of changes due to SMF exposure, and digital image analysis detected delicate textural changes even in a group where pathohistological or biochemical alterations were not detected.

Outcomes measured

Brain fatty acid (FA) composition (thin layer chromatography)
Digital image analysis (DIA) texture/image parameters
Pathohistological alterations (mentioned as assessed)
Biochemical alterations (mentioned as assessed)

Limitations

Sample size not reported in the provided abstract/metadata
Only male mice studied
Exposure duration limited to 1 h/day for five days (subacute)
Outcomes described qualitatively in the abstract; effect sizes/statistical details not provided

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "static",
    "source": "static magnetic field exposure (whole-body)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "1 h/day for five days (subacute); 128 mT highly homogeneous SMF; orientation aligned vs opposite to vertical component of geomagnetic field"
  },
  "population": "Swiss-Webster male mice",
  "sample_size": null,
  "outcomes": [
    "Brain fatty acid (FA) composition (thin layer chromatography)",
    "Digital image analysis (DIA) texture/image parameters",
    "Pathohistological alterations (mentioned as assessed)",
    "Biochemical alterations (mentioned as assessed)"
  ],
  "main_findings": "Subacute whole-body exposure to a 128 mT highly homogeneous static magnetic field produced different outcomes depending on whether the field orientation was aligned with, or opposite to, the vertical component of the geomagnetic field. Brain fatty acid composition suggested a possible sequence of changes due to SMF exposure, and digital image analysis detected delicate textural changes even in a group where pathohistological or biochemical alterations were not detected.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in the provided abstract/metadata",
    "Only male mice studied",
    "Exposure duration limited to 1 h/day for five days (subacute)",
    "Outcomes described qualitatively in the abstract; effect sizes/statistical details not provided"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "SMF",
    "128 mT",
    "geomagnetic field orientation",
    "mouse",
    "brain tissue",
    "fatty acids",
    "thin layer chromatography",
    "digital image analysis",
    "texture analysis",
    "fractal analysis",
    "multifractal analysis",
    "gray level co-occurrence matrix",
    "pathohistology"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.2,
      "reason": "Static magnetic field exposure may be relevant to occupational SMF contexts, though this study is in mice and not explicitly occupational."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.etap.2022.103853
PubMed: 35318121

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