Selenium supplementation ameliorates static magnetic field-induced disorders in antioxidant status in rat tissues.

Environmental toxicology and pharmacology · 2011 · Mixed · Low evidence

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MixedLow evidencePaper 3263

Study snapshot

PublicationEnvironmental toxicology and pharmacology · 2011

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

The aim of this study was to investigate the effect of selenium supplementation on the antioxidant enzymatic system (such as GPx, GR and SOD), GSH and selenium level in liver, kidney, muscle and brain of static magnetic field (SMF) exposed rats. Male adult rats were divided into control rats (n=6), SMF-exposed rats (128 mT; 1h/day for 5 days), selenium-treated rats (Na(2)SeO(3), 0.2mg/l, in drinking water for 4 weeks) and co-exposed rats (selenium for 4 weeks and SMF during the last 5 consecutive days). Sub-acute exposure to SMF induces a decrease of selenium levels in kidney, muscle and brain. Our results also revealed a decrease of GPx activities in kidney and muscle. By contrast, SMF exposure increased total GSH levels and total SOD activities in liver, while glutathione reductase activity is unaffected. Selenium supplementation in SMF-exposed rats restored selenium levels in kidney, muscle and brain and elevated the activities of GPx in kidney and muscle to those of control group. In the liver, selenium supplementation failed to bring down the elevated levels of total GSH and SOD activity. Our investigations suggested that sub-acute exposure to SMF altered the antioxidant response by decreasing the level of total selenium in kidney, muscle and brain. Interestingly, selenium supplementation ameliorates antioxidant capacity in rat tissues exposed to SMF.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationMale adult rats

Sample size24

Exposurestatic · 1 h/day for 5 days (SMF exposure); selenium given for 4 weeks with SMF during last 5 consecutive days in co-exposed group

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Sub-acute static magnetic field exposure (128 mT; 1 h/day for 5 days) decreased selenium levels in kidney, muscle, and brain and decreased GPx activity in kidney and muscle; it increased total GSH and total SOD activity in liver, while GR activity was unaffected. Selenium supplementation (Na2SeO3, 0.2 mg/L in drinking water for 4 weeks) in SMF-exposed rats restored selenium levels in kidney, muscle, and brain and raised GPx activity in kidney and muscle to control levels, but did not reduce the elevated liver GSH and SOD activity.

Outcomes measured

Glutathione peroxidase (GPx) activity
Glutathione reductase (GR) activity
Superoxide dismutase (SOD) activity
Total glutathione (GSH) levels
Tissue selenium levels (liver, kidney, muscle, brain)

Limitations

Small group sizes (n=6 per group)
Animal study; generalizability to humans not addressed in abstract
Short SMF exposure duration (5 days)
Only antioxidant/biochemical endpoints reported; no clinical or functional outcomes described

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "static",
    "source": "static magnetic field",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "1 h/day for 5 days (SMF exposure); selenium given for 4 weeks with SMF during last 5 consecutive days in co-exposed group"
  },
  "population": "Male adult rats",
  "sample_size": 24,
  "outcomes": [
    "Glutathione peroxidase (GPx) activity",
    "Glutathione reductase (GR) activity",
    "Superoxide dismutase (SOD) activity",
    "Total glutathione (GSH) levels",
    "Tissue selenium levels (liver, kidney, muscle, brain)"
  ],
  "main_findings": "Sub-acute static magnetic field exposure (128 mT; 1 h/day for 5 days) decreased selenium levels in kidney, muscle, and brain and decreased GPx activity in kidney and muscle; it increased total GSH and total SOD activity in liver, while GR activity was unaffected. Selenium supplementation (Na2SeO3, 0.2 mg/L in drinking water for 4 weeks) in SMF-exposed rats restored selenium levels in kidney, muscle, and brain and raised GPx activity in kidney and muscle to control levels, but did not reduce the elevated liver GSH and SOD activity.",
  "effect_direction": "mixed",
  "limitations": [
    "Small group sizes (n=6 per group)",
    "Animal study; generalizability to humans not addressed in abstract",
    "Short SMF exposure duration (5 days)",
    "Only antioxidant/biochemical endpoints reported; no clinical or functional outcomes described"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "SMF",
    "selenium supplementation",
    "Na2SeO3",
    "antioxidant enzymes",
    "GPx",
    "SOD",
    "glutathione",
    "rat tissues",
    "liver",
    "kidney",
    "muscle",
    "brain"
  ],
  "suggested_hubs": [
    {
      "slug": "static-magnetic-fields",
      "weight": 0.9,
      "reason": "Study examines biological effects of static magnetic field exposure (128 mT) in rats."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.etap.2010.09.010
PubMed: 21787674

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