Biological effects of cell-phone radiofrequency waves exposure on fertilization in mice; an in vivo and in vitro study

2018 · Harm · Low evidence

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HarmLow evidencePaper 2087

Compared with control, groups exposed 5 h/day, 10 h/day (standby), and 1 h/day (active) had significantly fewer two-cell embryos and significantly more dead embryos. Five hours/day exposure decreased grade-A embryos and increased grade-B/C/D embryos. Ten hour…

Study snapshot

Publicationmanual · 2018

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Biological effects of cell-phone radiofrequency waves exposure on fertilization in mice; an in vivo and in vitro study Fatehi D, Anjomshoa M, Mohammadi M, Seify M, Rostamzadeh A. Biological effects of cell-phone radiofrequency waves exposure on fertilization in mice; an in vivo and in vitro study. Middle East Fertility Society Journal, 23(2):148-153. June 2018. Abstract Increasing use of cell-phone is one of the most important risk factors for population health. We designed an experimental study aimed at evaluating the effects of cell-phone radiofrequency (RF) waves exposure on fertilization in mice. Two hundred male and female NMRI-mice were used. One hundred males divided in five groups (n = 20) as control and exposed groups. Those irradiated with cell-phone RF in "Standby-mode" 1, 5 and 10 h daily named groups II, III and IV; respectively. Group V irradiated with cell-phone on "Active-mode" one hour daily. After 30 days irradiation, 50 males and 50 females were kept 24 h to assess their embryos. Fifty males were scarified to evaluate both in vitro and in vivo parameters, and 50 females received PMSG & HCG for both quantitative and qualitative evaluation. Comparing groups III, IV and V with control-group showed significantly decreased in the number of two-cell embryos (p = .000); however, a significant increase was found in the number of dead embryos (p = .000). Furthermore, 5 h daily irradiation significantly decreased grade-A embryos (p = .015); while, it significantly increased grade-B, C and D embryos (p-values = 0.026, 0.007, 0.006; respectively). Moreover, comparing groups IV and V to control-group, significant increase was found in pregnancy duration (p = .005, p = .009; respectively). However, in the mentioned groups a significant decrease was seen in number of newborn mice (p = .001, p = .004; respectively). In conclusion our findings showed that the cell-phone radiation can affect development of embryos as well as the number of newborn and pregnancy duration in NMRI-mouse, which might be a significant cause of reproductive failure. Open access paper: sciencedirect.com The applied frequency of the waves was 900 MHz irradiated from a Nokia cell-phone (Nokia 1100, Finland). In case of irradiation, the distance between cell-phone and mouse was 10 cm.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationNMRI mice (male and female)

Sample size200

ExposureRF · 900 MHz · Standby-mode: 1, 5, or 10 h daily for 30 days; Active-mode: 1 h daily for 30 days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

number of two-cell embryos
number of dead embryos
embryo quality grades (A–D)
pregnancy duration
number of newborn mice

Limitations

SAR not reported
Exposure characterization limited (e.g., field strength not provided); distance reported as 10 cm
Animal model; generalizability to humans not addressed in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "mobile phone",
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "Standby-mode: 1, 5, or 10 h daily for 30 days; Active-mode: 1 h daily for 30 days"
  },
  "population": "NMRI mice (male and female)",
  "sample_size": 200,
  "outcomes": [
    "number of two-cell embryos",
    "number of dead embryos",
    "embryo quality grades (A–D)",
    "pregnancy duration",
    "number of newborn mice"
  ],
  "main_findings": "Compared with control, groups exposed 5 h/day, 10 h/day (standby), and 1 h/day (active) had significantly fewer two-cell embryos and significantly more dead embryos. Five hours/day exposure decreased grade-A embryos and increased grade-B/C/D embryos. Ten hours/day standby and 1 hour/day active exposure increased pregnancy duration and decreased the number of newborn mice.",
  "effect_direction": "harm",
  "limitations": [
    "SAR not reported",
    "Exposure characterization limited (e.g., field strength not provided); distance reported as 10 cm",
    "Animal model; generalizability to humans not addressed in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "radiofrequency",
    "mobile phone",
    "900 MHz",
    "Nokia 1100",
    "mice",
    "NMRI",
    "fertilization",
    "embryo development",
    "pregnancy duration",
    "newborn count",
    "in vivo",
    "in vitro"
  ],
  "suggested_hubs": [
    {
      "slug": "mobile-phones",
      "weight": 0.9,
      "reason": "Exposure source is a cell phone (900 MHz) with standby/active modes."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: Not supplied

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