Myrtenal improves memory deficits in mice exposed to radiofrequency radiation during gestational & neonatal development via enhancing oxido-inflammatory, and neurotransmitter functions

Heliyon · 2023 · Mixed · Low evidence

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MixedLow evidencePaper 499

Study snapshot

PublicationHeliyon · 2023

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Myrtenal improves memory deficits in mice exposed to radiofrequency radiation during gestational & neonatal development via enhancing oxido-inflammatory, and neurotransmitter functions Akefe IO, Nyan ES, Adegoke VA, Lamidi IY, Ameh MP, Chidiebere U, Ubah SA, Ajayi IE. Myrtenal improves memory deficits in mice exposed to radiofrequency-electromagnetic radiation during gestational and neonatal development via enhancing oxido-inflammatory, and neurotransmitter functions. Heliyon. 2023 Apr 8;9(4):e15321. doi: 10.1016/j.heliyon.2023.e15321 Abstract Objective: Radiofrequency-electromagnetic radiation (RF-EMR) exposure during gestational and neonatal development may interact with the foetus and neonate considered hypersensitive to RF-EMR, consequently resulting in developmental defects associated with neuropsychological and neurobehavioral disorders, including learning and memory impairment. This study assessed the potential of Myrtenal (Myrt) to improve memory deficits in C57BL/6 mice exposed to RF-EMR during gestational and neonatal development. Method: Thirty-five male mice were randomly allocated into 5 cohorts, each comprising of 7 mice. Group I was administered vehicle, Group II: RF-EMR (900 MHz); Group III: RF-EMR (900 MHz) + 100 mg/kg Myrt; Group IV: RF-EMR (900 MHz) + 200 mg/kg Myrt; and Group V: RF-EMR (900 MHz) + donepezil 0.5 mg/kg. Results: Myrt treatment improved short-term memory performance in RF-EMR (900 MHz)-exposed mice by augmenting activities of endogenous antioxidant enzymes and proinflammatory cytokines, thereby protecting the brain from oxido-inflammatory stress. Additionally, Myrt restored the homeostasis of neurotransmitters in RF-EMR-exposed animals. Conclusion: Results from the present study shows that exposure to RF-EMR impaired short-term memory in animals and altered the response of markers of oxido-inflammatory stress, and neurotransmitters. It is therefore conceivable that the recommendation of Myrt-enriched fruits may offer protective benefits for foeti and neonates prone to RF-EMR exposure. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationC57BL/6 mice (male; exposed during gestational and neonatal development)

Sample size35

ExposureRF · 900 MHz · during gestational and neonatal development

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In this mouse study, RF-EMR exposure (900 MHz) during gestational and neonatal development was associated with impaired short-term memory and altered oxido-inflammatory stress markers and neurotransmitters. Myrtenal treatment (100 or 200 mg/kg) improved short-term memory performance in RF-EMR-exposed mice and was reported to augment antioxidant enzyme activities, affect proinflammatory cytokines, and restore neurotransmitter homeostasis; donepezil was included as a comparator.

Outcomes measured

Short-term memory performance
Endogenous antioxidant enzyme activities
Proinflammatory cytokines
Markers of oxido-inflammatory stress
Neurotransmitter homeostasis

Limitations

Exposure source and exposure protocol details (e.g., duration per day, field strength/SAR) not provided in the abstract
Only male mice were studied (as stated in methods)
Sample size per group was small (n=7)
Outcomes and statistical details are not described in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 900,
    "sar_wkg": null,
    "duration": "during gestational and neonatal development"
  },
  "population": "C57BL/6 mice (male; exposed during gestational and neonatal development)",
  "sample_size": 35,
  "outcomes": [
    "Short-term memory performance",
    "Endogenous antioxidant enzyme activities",
    "Proinflammatory cytokines",
    "Markers of oxido-inflammatory stress",
    "Neurotransmitter homeostasis"
  ],
  "main_findings": "In this mouse study, RF-EMR exposure (900 MHz) during gestational and neonatal development was associated with impaired short-term memory and altered oxido-inflammatory stress markers and neurotransmitters. Myrtenal treatment (100 or 200 mg/kg) improved short-term memory performance in RF-EMR-exposed mice and was reported to augment antioxidant enzyme activities, affect proinflammatory cytokines, and restore neurotransmitter homeostasis; donepezil was included as a comparator.",
  "effect_direction": "mixed",
  "limitations": [
    "Exposure source and exposure protocol details (e.g., duration per day, field strength/SAR) not provided in the abstract",
    "Only male mice were studied (as stated in methods)",
    "Sample size per group was small (n=7)",
    "Outcomes and statistical details are not described in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "radiofrequency-electromagnetic radiation",
    "RF-EMR",
    "900 MHz",
    "gestational exposure",
    "neonatal exposure",
    "mice",
    "memory deficits",
    "short-term memory",
    "myrtenal",
    "oxidative stress",
    "inflammation",
    "neurotransmitters",
    "donepezil"
  ],
  "suggested_hubs": [
    {
      "slug": "prenatal-exposure",
      "weight": 0.78,
      "reason": "RF-EMR exposure described during gestational and neonatal development with neurobehavioral outcomes in offspring."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.heliyon.2023.e15321
PubMed: 37123912

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