RF Safe

[Effects of microwave radiation on lipid peroxidation and the content of neurotransmitters in mice].

Wei sheng yan jiu = Journal of hygiene research · 2000 · Mixed · Low evidence

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MixedLow evidencePaper 3936

At 1 mW/cm2 (SAR 0.22 W/kg), microwave-exposed mice showed increased blood GSH-Px activity, decreased blood MDA concentration, and increased brain NE concentration compared with sham exposure. No significant changes were found at 2 or 5 mW/cm2 (SAR 0.44 or 1.…

Study snapshot

PublicationWei sheng yan jiu = Journal of hygiene research · 2000
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

Male LACA mice were exposed to 900 MHz microwaves at the power densities of 0,1,2 and 5 mW/cm2. The resulting specific absorption rates(SARs) were 0, 0.22, 0.44 and 1.10 W/kg respectively. Animals were exposed at the dosage of 1 hour a day for 35 days. The results showed that the activity of glutathione peroxidase (GSH-Px) increased and the concentration of malondialdehyde (MDA) decreased in blood, and the concentration of noradrenaline (NE) increased in brains in the microwave exposed groups at 1 mW/cm2 compared with the sham-exposed group. But no significant changes were found in the microwave exposed groups at 2 and 5 mW/cm2. No significant changes of the concentrations of 5-hydroxytryptamine(5-HT), 5-hydroxyindole acetic acid(5-HIAA) and dopamie(DA) in brains were found.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationMale LACA mice
Sample sizeNot supplied
ExposureRF · 900 MHz · 1.1 W/kg · 1 hour/day for 35 days
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

At 1 mW/cm2 (SAR 0.22 W/kg), microwave-exposed mice showed increased blood GSH-Px activity, decreased blood MDA concentration, and increased brain NE concentration compared with sham exposure. No significant changes were found at 2 or 5 mW/cm2 (SAR 0.44 or 1.10 W/kg). No significant changes were observed for brain 5-HT, 5-HIAA, or DA concentrations.

Outcomes measured

  • Glutathione peroxidase (GSH-Px) activity in blood
  • Malondialdehyde (MDA) concentration in blood
  • Brain noradrenaline (NE) concentration
  • Brain 5-hydroxytryptamine (5-HT) concentration
  • Brain 5-hydroxyindole acetic acid (5-HIAA) concentration
  • Brain dopamine (DA) concentration

Limitations

  • Sample size not reported in abstract
  • Only male mice studied
  • Limited outcome set (biochemical markers and selected neurotransmitters only)
  • Non-monotonic dose-response reported (effects at 1 mW/cm2 but not at higher power densities)
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 900,
    "sar_wkg": 1.1,
    "duration": "1 hour/day for 35 days"
  },
  "population": "Male LACA mice",
  "sample_size": null,
  "outcomes": [
    "Glutathione peroxidase (GSH-Px) activity in blood",
    "Malondialdehyde (MDA) concentration in blood",
    "Brain noradrenaline (NE) concentration",
    "Brain 5-hydroxytryptamine (5-HT) concentration",
    "Brain 5-hydroxyindole acetic acid (5-HIAA) concentration",
    "Brain dopamine (DA) concentration"
  ],
  "main_findings": "At 1 mW/cm2 (SAR 0.22 W/kg), microwave-exposed mice showed increased blood GSH-Px activity, decreased blood MDA concentration, and increased brain NE concentration compared with sham exposure. No significant changes were found at 2 or 5 mW/cm2 (SAR 0.44 or 1.10 W/kg). No significant changes were observed for brain 5-HT, 5-HIAA, or DA concentrations.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Only male mice studied",
    "Limited outcome set (biochemical markers and selected neurotransmitters only)",
    "Non-monotonic dose-response reported (effects at 1 mW/cm2 but not at higher power densities)"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "900 MHz",
    "microwave radiation",
    "RF exposure",
    "specific absorption rate",
    "mice",
    "lipid peroxidation",
    "glutathione peroxidase",
    "malondialdehyde",
    "noradrenaline",
    "serotonin",
    "dopamine"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 12725036

Read the original paper →

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