Evidence of oxidative stress after continuous exposure to Wi-Fi radiation in rat model

2018 · Mixed · Low evidence

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MixedLow evidencePaper 1991

Male Wister rats exposed continuously to 2.45 GHz RF radiation from a Wi-Fi device for 24 h/day for 10 weeks showed a significant decrease in plasma total antioxidant capacity and in CAT, GSH-Px, and SOD activities versus controls (P<0.05), while GST activity…

Study snapshot

Publicationmanual · 2018

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Evidence of oxidative stress after continuous exposure to Wi-Fi radiation in rat model Kamali K, Taravati A, Sayyadi S, Gharib FZ, Maftoon H. Evidence of oxidative stress after continuous exposure to Wi-Fi radiation in rat model. Environ Sci Pollut Res Int. 2018 Oct 21. doi: 10.1007/s11356-018-3482-0. Abstract Exposure to electromagnetic radiation (EMR) is rapidly increasing in everyday environment, consequently conferring potential health effects. Oxidative stress is emerging as a mechanism implicated in pathophysiology and progression of various diseases. To our knowledge, no report has been made on the status of antioxidant redox systems after continuous exposure to radiofrequency radiation emitted from a Wi-Fi access point in animal model so far. Therefore, we aimed to continuously subject rats in the experimental group to radiofrequency (RF) radiation emitted from a commercially available Wi-Fi device. Male Wister rats were exposed to 2.45 GHz RF radiation emitted from a Wi-Fi for 24 h/day for 10 consecutive weeks. In order to assess the change in antioxidant redox system of plasma after continuous exposure to a Wi-Fi device, the total antioxidant capacity of plasma, level of thiobarbituric acid reactive substances, concentration of reduced glutathione (GSH), and activity of different enzymatic antioxidants, e.g., superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GSH-Px], and glutathione S-transferase [GST], were measured. In the Wi-Fi exposed group, a significant decrease was detected in total antioxidant capacity of plasma and the activities of several antioxidant enzymes, including CAT, GSH-Px, and SOD (P < 0.05). Meanwhile, the GST activity was significantly increased in this group (P < 0.05). However, no significant changes were found in GSH and TBARS levels following exposure to RF radiation. According to the results, oxidative defense system in rats exposed to Wi-Fi signal was significantly affected compared to the control group. Further studies are needed to better understand the possible biological mechanisms of EMR emitted from Wi-Fi device and relevant outcomes. ncbi.nlm.nih.gov Conclusion According to the results of the current research, long-term exposure to EMR emitted from wireless devices had adverse effects on the antioxidant potential of blood. Therefore, to protect individuals from harmful effects of Wi-Fi signals, it is advised to limit the use of such devices for household and occupational activities, if possible. This study may stimulate future helpful research in the development of new protective or therapeutic approaches. In addition, it is recommended that the target tissues of EMR emitted from wireless devices and the level of other mediators be investigated to understand the exact molecular mechanism and site of action upon continuous exposure to such radiations.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationMale Wister rats

Sample sizeNot supplied

ExposureRF · 2450 MHz · 24 h/day for 10 consecutive weeks

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Total antioxidant capacity (plasma)
Thiobarbituric acid reactive substances (TBARS)
Reduced glutathione (GSH)
Superoxide dismutase (SOD) activity
Catalase (CAT) activity
Glutathione peroxidase (GSH-Px) activity
Glutathione S-transferase (GST) activity

Limitations

Sample size not reported in provided abstract/metadata
SAR or exposure intensity not reported
Only plasma antioxidant/oxidative stress markers assessed; target tissues not evaluated in the provided text

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": "wi-fi",
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": "24 h/day for 10 consecutive weeks"
  },
  "population": "Male Wister rats",
  "sample_size": null,
  "outcomes": [
    "Total antioxidant capacity (plasma)",
    "Thiobarbituric acid reactive substances (TBARS)",
    "Reduced glutathione (GSH)",
    "Superoxide dismutase (SOD) activity",
    "Catalase (CAT) activity",
    "Glutathione peroxidase (GSH-Px) activity",
    "Glutathione S-transferase (GST) activity"
  ],
  "main_findings": "Male Wister rats exposed continuously to 2.45 GHz RF radiation from a Wi-Fi device for 24 h/day for 10 weeks showed a significant decrease in plasma total antioxidant capacity and in CAT, GSH-Px, and SOD activities versus controls (P<0.05), while GST activity significantly increased (P<0.05). No significant changes were observed in GSH or TBARS levels.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "SAR or exposure intensity not reported",
    "Only plasma antioxidant/oxidative stress markers assessed; target tissues not evaluated in the provided text"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "Wi-Fi",
    "radiofrequency radiation",
    "2.45 GHz",
    "rat model",
    "oxidative stress",
    "antioxidant enzymes",
    "total antioxidant capacity",
    "SOD",
    "CAT",
    "GSH-Px",
    "GST",
    "TBARS",
    "GSH"
  ],
  "suggested_hubs": [
    {
      "slug": "school-wi-fi",
      "weight": 0.6,
      "reason": "Study examines biological effects of Wi-Fi (2.45 GHz) exposure."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1007/s11356-018-3482-0
PubMed: Not supplied

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