The effects of radiofrequency radiation on mice fetus weight, length and tissues

2018 · Mixed · Low evidence

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MixedLow evidencePaper 1968

In the exposure group (915 MHz; 0.045 µW/cm2; 8 h/day for 10 days), the authors report significant increases in fetus weight and crown-rump length, and tissue abnormalities including enlarged liver and tail deformation. In the exposure plus vitamin C group (2…

Study snapshot

Publicationmanual · 2018

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

The effects of radiofrequency radiation on mice fetus weight, length and tissues Alimohammadi I, Ahtarinezhad A, Mohamadzadeh Asl B, Masruri B, Moghadasi N. The effects of radiofrequency radiation on mice fetus weight, length and tissues. Data in Brief. 19:2189-2194. August 2018. doi.org. Value of data * The result of this study is useful for workers and users that are exposed to radiofrequency radiation as a physical agent. * Investigation of radiofrequency radiation effects in organogenesis period during pregnancy and protective role of vitamin C as a water-soluble antioxidant in body tissues and fluids are the innovation of this study. * These data showed changes of growth parameters and abnormalities in tissues as the result of radiofrequency radiation exposure which could be useful for some organization such as Ministry of Health and Medical Education to recognize possible risks in vulnerable groups like pregnant women and their embryos and protect them more effective. Abstract The public concern of harmful effects of radiofrequency radiation exposure, especially with rapid increase in the use of wireless and telecommunication devices, is increasing. Some studies show fetal and developmental abnormalities as the result of radiofrequency radiation exposure. We aimed to investigate possible teratogenic effects of radiofrequency in 915 MHz on mice fetus and protective role of vitamin C. 21 pregnant mice were divided into 3 groups. Control group was in normal condition without any stressor agent. Exposure group was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The exposure plus vitamin C group received 200 mg/kg vitamin C by gavage and was exposed to 915 MHz RFR (8 h/day for 10 days) and 0.045 µw/cm2 power density. The fetus weight, C-R length were measured by digital balance and caliper. Tissues were assessed after staining with H & E. Our results showed significant increase in fetus weight and C-R length and also enlarged liver, tail deformation in mice fetus in exposure group. Although usage of vitamin C caused significant decrease in mentioned parameters. The outcome of this study confirms the effects of radiofrequency radiation on growth parameters such as body weight, length and some tissues in mice fetuses and protective effect of vitamin C. However more studies on non-ionization radiation in different frequencies and severity, during pregnancy are needed to clarify the exact mechanisms of these changes and better protection. Open access paper: sciencedirect.com

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationPregnant mice and their fetuses

Sample size21

ExposureRF · 915 MHz · 8 h/day for 10 days

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Outcomes measured

Fetus weight
Crown-rump (C-R) length
Histological tissue changes/abnormalities (e.g., liver enlargement, tail deformation)
Effect of vitamin C on measured parameters

Limitations

No SAR reported (only power density provided)
Animal study; generalizability to humans not established in abstract
Exposure source/setup details not described in abstract
Outcomes described as significant but statistical details not provided in abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "RF",
    "source": null,
    "frequency_mhz": 915,
    "sar_wkg": null,
    "duration": "8 h/day for 10 days"
  },
  "population": "Pregnant mice and their fetuses",
  "sample_size": 21,
  "outcomes": [
    "Fetus weight",
    "Crown-rump (C-R) length",
    "Histological tissue changes/abnormalities (e.g., liver enlargement, tail deformation)",
    "Effect of vitamin C on measured parameters"
  ],
  "main_findings": "In the exposure group (915 MHz; 0.045 µW/cm2; 8 h/day for 10 days), the authors report significant increases in fetus weight and crown-rump length, and tissue abnormalities including enlarged liver and tail deformation. In the exposure plus vitamin C group (200 mg/kg), vitamin C was reported to significantly decrease the mentioned parameters compared with exposure alone.",
  "effect_direction": "mixed",
  "limitations": [
    "No SAR reported (only power density provided)",
    "Animal study; generalizability to humans not established in abstract",
    "Exposure source/setup details not described in abstract",
    "Outcomes described as significant but statistical details not provided in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "radiofrequency radiation",
    "915 MHz",
    "pregnancy",
    "mice",
    "fetuses",
    "teratogenic effects",
    "organogenesis",
    "vitamin C",
    "power density",
    "histology"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.35,
      "reason": "The paper notes usefulness for workers/users exposed to radiofrequency radiation."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.dib.2018.06.107
PubMed: Not supplied

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