Effects of an electric field on sleep quality and life span mediated by ultraviolet (UV)-A/blue light photoreceptor CRYPTOCHROME in Drosophila

2021 · Benefit · Low evidence

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Study snapshot

Publicationmanual · 2021

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

Effects of an electric field on sleep quality and life span mediated by ultraviolet (UV)-A/blue light photoreceptor CRYPTOCHROME in Drosophila Haruhisa Kawasaki, Hideyuki Okano, Takaki Nedachi, Yuzo Nakagawa-Yagi, Akikuni Hara, Norio Ishida. Effects of an electric field on sleep quality and life span mediated by ultraviolet (UV)-A/blue light photoreceptor CRYPTOCHROME in Drosophila. Sci Rep. 2021 Oct 15;11(1):20543. doi: 10.1038/s41598-021-99753-4. Abstract Although electric fields (EF) exert beneficial effects on animal wound healing, differentiation, cancers and rheumatoid arthritis, the molecular mechanisms of these effects have remained unclear about a half century. Therefore, we aimed to elucidate the molecular mechanisms underlying EF effects in Drosophila melanogaster as a genetic animal model. Here we show that the sleep quality of wild type (WT) flies was improved by exposure to a 50-Hz (35 kV/m) constant electric field during the day time, but not during the night time. The effect was undetectable in cryptochrome mutant (cryb) flies. Exposure to a 50-Hz electric field under low nutrient conditions elongated the lifespan of male and female WT flies by ~ 18%, but not of several cry mutants and cry RNAi strains. Metabolome analysis indicated that the adenosine triphosphate (ATP) content was higher in intact WT than cry gene mutant strains exposed to an electric field. A putative magnetoreceptor protein and UV-A/blue light photoreceptor, CRYPTOCHROME (CRY) is involved in electric field (EF) receptors in animals. The present findings constitute hitherto unknown genetic evidence of a CRY-based system that is electric field sensitive in animals. Open access paper: nature.com

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationDrosophila melanogaster (wild type and cryptochrome/cry mutant and RNAi strains)

Sample sizeNot supplied

ExposureELF

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Exposure to a 50-Hz (35 kV/m) constant electric field during daytime improved sleep quality in wild-type flies, but this effect was not detected during nighttime and was undetectable in cryptochrome mutant (cryb) flies. Under low nutrient conditions, 50-Hz electric field exposure elongated lifespan of male and female wild-type flies by ~18%, but not in several cry mutants and cry RNAi strains. Metabolome analysis indicated higher ATP content in intact wild-type than cry mutant strains exposed to an electric field.

Outcomes measured

sleep quality
life span
ATP content (metabolome analysis)

Limitations

Sample size not reported in provided abstract/metadata
Exposure duration and detailed protocol not reported in provided abstract/metadata
Findings are from an animal (Drosophila) model; human relevance not addressed in provided abstract/metadata

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": "other",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Drosophila melanogaster (wild type and cryptochrome/cry mutant and RNAi strains)",
  "sample_size": null,
  "outcomes": [
    "sleep quality",
    "life span",
    "ATP content (metabolome analysis)"
  ],
  "main_findings": "Exposure to a 50-Hz (35 kV/m) constant electric field during daytime improved sleep quality in wild-type flies, but this effect was not detected during nighttime and was undetectable in cryptochrome mutant (cryb) flies. Under low nutrient conditions, 50-Hz electric field exposure elongated lifespan of male and female wild-type flies by ~18%, but not in several cry mutants and cry RNAi strains. Metabolome analysis indicated higher ATP content in intact wild-type than cry mutant strains exposed to an electric field.",
  "effect_direction": "benefit",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Exposure duration and detailed protocol not reported in provided abstract/metadata",
    "Findings are from an animal (Drosophila) model; human relevance not addressed in provided abstract/metadata"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "electric field",
    "ELF",
    "50-Hz",
    "35 kV/m",
    "Drosophila melanogaster",
    "sleep quality",
    "lifespan",
    "cryptochrome",
    "CRY",
    "ATP",
    "metabolomics"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1038/s41598-021-99753-4
PubMed: Not supplied

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