Gender and Age Differences in the Suppressive Effect of a 50 Hz Electric Field on the Immobilization-Induced Increase of Plasma Glucocorticoid in Mice

2019 · Benefit · Low evidence

← Research stream

BenefitLow evidencePaper 1651

In immobilized mice, exposure to a 50 Hz, 10 kV/m electric field suppressed the immobilization-induced increase in plasma glucocorticoid. The suppressive effect was reported to occur regardless of gender or age.

Study snapshot

Publicationmanual · 2019

Study typeanimal

Reported directionBenefit

Evidence ratingLow

Abstract

Gender and Age Differences in the Suppressive Effect of a 50 Hz Electric Field on the Immobilization-Induced Increase of Plasma Glucocorticoid in Mice Harakawa S, Hori T, Nedachi T, Suzuki H. Gender and Age Differences in the Suppressive Effect of a 50 Hz Electric Field on the Immobilization-Induced Increase of Plasma Glucocorticoid in Mice. Bioelectromagnetics. 2019 Dec 12. doi: 10.1002/bem.22238. Abstract We developed an experimental system to characterize the suppressive effect of extremely low-frequency (ELF) electric fields (EFs) on the stress response. We assessed differences in the EF effects by age and gender. Control, EF-alone, immobilization-alone, and co-treated groups were subjected to an EF (50 Hz, 10 kV/m). Co-treated mice were exposed to the EF for 60 min, with immobilization during the latter half. Our results indicate that the suppressive effects of ELF EFs on the stress response in immobilized mice occur regardless of gender or age. As stress plays an important role in the onset and progression of various diseases, these findings may have broad implications for understanding the efficacy of EFs in animal, and perhaps human, health ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionbenefit

PopulationMice

Sample sizeNot supplied

ExposureELF · 0.05 MHz · 60 min (immobilization during latter half for co-treated group)

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Outcomes measured

Plasma glucocorticoid (stress response) under immobilization
Differences by gender
Differences by age

Limitations

Sample size not reported in provided abstract/metadata
Details of mouse strain, ages, and sex distribution not provided in provided abstract/metadata
Outcome measurement methods and statistical results not provided in provided abstract/metadata

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 0.05,
    "sar_wkg": null,
    "duration": "60 min (immobilization during latter half for co-treated group)"
  },
  "population": "Mice",
  "sample_size": null,
  "outcomes": [
    "Plasma glucocorticoid (stress response) under immobilization",
    "Differences by gender",
    "Differences by age"
  ],
  "main_findings": "In immobilized mice, exposure to a 50 Hz, 10 kV/m electric field suppressed the immobilization-induced increase in plasma glucocorticoid. The suppressive effect was reported to occur regardless of gender or age.",
  "effect_direction": "benefit",
  "limitations": [
    "Sample size not reported in provided abstract/metadata",
    "Details of mouse strain, ages, and sex distribution not provided in provided abstract/metadata",
    "Outcome measurement methods and statistical results not provided in provided abstract/metadata"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low-frequency",
    "ELF",
    "electric field",
    "50 Hz",
    "10 kV/m",
    "stress response",
    "immobilization",
    "plasma glucocorticoid",
    "mice",
    "age differences",
    "gender differences"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.2,
      "reason": "ELF electric-field exposure (50 Hz) may relate to power-frequency environments, though the study is in mice and no occupational context is stated."
    }
  ]
}

AI can be wrong. Always verify against the paper.

AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.22238
PubMed: Not supplied

Read the original paper →

Related papers

← Back to the Research Library