On the origin of the biological effects of time varying magnetic fields: quantitative insights

Journal of materials chemistry. B · 2024 · Mixed · Insufficient evidence

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MixedInsufficient evidencePaper 133

Study snapshot

PublicationJournal of materials chemistry. B · 2024

Study typeother

Reported directionMixed

Evidence ratingInsufficient

Abstract

On the origin of the biological effects of time varying magnetic fields: quantitative insights Ravikumar K, Roy Choudury AN, Dubey AK, Kumaran V, Basu B. On the origin of the biological effects of time varying magnetic fields: quantitative insights. J Mater Chem B. 2024 Jul 3. doi:10.1039/d4tb00362d. Abstract In a number of recently published experimental studies from our research group, the positive impact of magnetic stimuli (static/pulsed) on cell functionality modulation or bactericidal effects, in vitro, has been established. In order to develop a theoretical understanding of such magnetobiological effects, the present study aimed to present two quantitative models to determine magnetic Maxwell stresses as well as pressure acting on the cell membrane, under the influence of a time varying magnetic field. The model predicts that magnetic field-induced stress on the cell/bacteria is dependent on the conductivity properties of the extracellular region, which is determined to be too low to cause any significant effect. However, the force on the cell/bacteria due to the induced electric field is more influential than that of the magnetic field, which has been used to determine the membrane tension that can cause membrane poration. With a known critical membrane tension for cells, the field parameters necessary to cause membrane rupture have been estimated. Based on the experimental results and theoretically predicted values, the field parameters can be classified into three regimes, wherein the magnetic fields cause no effect or result in biophysical stimulation or induce cell death due to membrane damage. Taken together, this work provides some quantitative insights into the impact of magnetic fields on biological systems. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeother

Effect directionmixed

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthInsufficientConfidence: 74% · Peer reviewed: yes

Main findings

The study presents quantitative models for magnetic Maxwell stresses/pressure on cell membranes under time-varying magnetic fields and predicts that magnetic-field-induced stress depends on extracellular conductivity and is too low to cause significant effects. It further predicts that forces due to the induced electric field are more influential and can be used to estimate membrane tension and field parameters required for membrane rupture, classifying field parameters into regimes of no effect, biophysical stimulation, or cell death due to membrane damage.

Outcomes measured

cell functionality modulation (in vitro)
bactericidal effects (in vitro)
magnetic Maxwell stresses
pressure acting on cell membrane
induced electric field force on cells/bacteria
membrane tension
membrane poration/rupture
cell death due to membrane damage

Limitations

The abstract describes modeling and references prior experimental studies but does not report specific experimental methods, exposure parameters, or quantitative results in the abstract.
No specific frequencies, field strengths, exposure durations, or sample sizes are provided in the abstract.
Findings are framed as model predictions and regime classifications without detailed validation data in the abstract.

View raw extracted JSON

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "time varying magnetic fields (static/pulsed magnetic stimuli)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "cell functionality modulation (in vitro)",
    "bactericidal effects (in vitro)",
    "magnetic Maxwell stresses",
    "pressure acting on cell membrane",
    "induced electric field force on cells/bacteria",
    "membrane tension",
    "membrane poration/rupture",
    "cell death due to membrane damage"
  ],
  "main_findings": "The study presents quantitative models for magnetic Maxwell stresses/pressure on cell membranes under time-varying magnetic fields and predicts that magnetic-field-induced stress depends on extracellular conductivity and is too low to cause significant effects. It further predicts that forces due to the induced electric field are more influential and can be used to estimate membrane tension and field parameters required for membrane rupture, classifying field parameters into regimes of no effect, biophysical stimulation, or cell death due to membrane damage.",
  "effect_direction": "mixed",
  "limitations": [
    "The abstract describes modeling and references prior experimental studies but does not report specific experimental methods, exposure parameters, or quantitative results in the abstract.",
    "No specific frequencies, field strengths, exposure durations, or sample sizes are provided in the abstract.",
    "Findings are framed as model predictions and regime classifications without detailed validation data in the abstract."
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "time varying magnetic fields",
    "static magnetic stimuli",
    "pulsed magnetic fields",
    "magnetobiological effects",
    "in vitro",
    "bactericidal",
    "cell membrane",
    "Maxwell stress",
    "induced electric field",
    "membrane tension",
    "poration",
    "membrane rupture"
  ],
  "suggested_hubs": [
    {
      "slug": "mechanisms-modeling",
      "weight": 0.9,
      "reason": "Presents quantitative theoretical models for stresses/forces and membrane effects under time-varying magnetic fields."
    },
    {
      "slug": "in-vitro-studies",
      "weight": 0.55,
      "reason": "Discusses in vitro cell functionality modulation and bactericidal effects (referenced and used for comparison)."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1039/d4tb00362d
PubMed: 38958687

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