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Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts

2021 · Mixed · Low evidence

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MixedLow evidencePaper 996

Intermittent exposure to 10 Hz pulsed magnetic fields at 1.0 mT for 2 weeks induced DNA damage, but did not produce other significant phenotypes of cellular senescence in 2BS cells.

Study snapshot

Publicationmanual · 2021
Study typein_vitro
Reported directionMixed
Evidence ratingLow

Abstract

Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts Sun Chuan, Huang Zheng, Qin Houbing, Zhang Jing, Wang Sanying, Xu Xiaogang, Ying Shibo, Mao Genxiang. Exposure to 10 Hz Pulsed Magnetic Fields Do Not Induce Cellular Senescence in Human Fetal Lung Fibroblasts. Frontiers in Public Health. 9:1657. 2021. doi: 10.3389/fpubh.2021.761069. Abstract Rapid population aging has led to a global burden of late-life diseases. As the largest risk factor for a multitude of age-related diseases, aging is not only the result of genotype but also closely related to external factors. With the rapid expansion in the usage of electromagnetic fields (EMFs), the effect of EMFs on aging has also attracted attention. Cells are the basic unit of organs and body tissues, and cellular senescence plays an important role in the aging process. The effect of EMFs on cellular senescence has been investigated in a few studies, but the information is limited, and the results are inconsistent; thus, further investigation is required. In this study, we investigated the effect of 10 Hz pulsed magnetic fields (MFs) on cellular senescence in a 2BS cell line, isolated from human fetal lung fibroblasts, and found that intermittent (1 d on/1 d off) exposure to 10 Hz pulsed MFs at 1.0 mT for 2 weeks induced DNA damage, but no other significant phenotype of cellular senescence in 2BS cells. Open access paper: frontiersin.org

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionmixed
Population2BS cell line (human fetal lung fibroblasts)
Sample sizeNot supplied
ExposureELF · 1e-05 MHz · Intermittent (1 d on/1 d off) exposure for 2 weeks
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Intermittent exposure to 10 Hz pulsed magnetic fields at 1.0 mT for 2 weeks induced DNA damage, but did not produce other significant phenotypes of cellular senescence in 2BS cells.

Outcomes measured

  • Cellular senescence phenotypes
  • DNA damage

Limitations

  • In vitro study (2BS cell line)
  • Sample size not reported in abstract
  • Exposure details beyond frequency, intensity, and schedule not reported in abstract
  • Senescence assessment methods/markers not specified in abstract
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "ELF",
    "source": null,
    "frequency_mhz": 1e-05,
    "sar_wkg": null,
    "duration": "Intermittent (1 d on/1 d off) exposure for 2 weeks"
  },
  "population": "2BS cell line (human fetal lung fibroblasts)",
  "sample_size": null,
  "outcomes": [
    "Cellular senescence phenotypes",
    "DNA damage"
  ],
  "main_findings": "Intermittent exposure to 10 Hz pulsed magnetic fields at 1.0 mT for 2 weeks induced DNA damage, but did not produce other significant phenotypes of cellular senescence in 2BS cells.",
  "effect_direction": "mixed",
  "limitations": [
    "In vitro study (2BS cell line)",
    "Sample size not reported in abstract",
    "Exposure details beyond frequency, intensity, and schedule not reported in abstract",
    "Senescence assessment methods/markers not specified in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "10 Hz",
    "pulsed magnetic fields",
    "ELF magnetic field",
    "1.0 mT",
    "2BS cells",
    "human fetal lung fibroblasts",
    "cellular senescence",
    "DNA damage",
    "aging"
  ],
  "suggested_hubs": [
    {
      "slug": "elf-emf",
      "weight": 0.9,
      "reason": "Study tests extremely low frequency (10 Hz) pulsed magnetic field exposure in vitro."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3389/fpubh.2021.761069
PubMed: Not supplied

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