Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells

Sci Rep · 2023 · Harm · Low evidence

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HarmLow evidencePaper 6749

Spinning oscillating magnetic fields (sOMF) produced cytotoxicity in two types of human glioma cells associated with a critical rise in superoxide. Trolox reversed the cytotoxic effect, supporting a causal role for ROS. The authors also report sOMF shrank GBM…

Study snapshot

PublicationSci Rep · 2023

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Raising reactive oxygen species (ROS) levels in cancer cells to cause macromolecular damage and cell death is a promising anticancer treatment strategy. Observations that electromagnetic fields (EMF) elevate intracellular ROS and cause cancer cell death, have led us to develop a new portable wearable EMF device that generates spinning oscillating magnetic fields (sOMF) to selectively kill cancer cells while sparing normal cells in vitro and to shrink GBM tumors in vivo through a novel mechanism. Here, we characterized the precise configurations and timings of sOMF stimulation that produce cytotoxicity due to a critical rise in superoxide in two types of human glioma cells. We also found that the antioxidant Trolox reverses the cytotoxic effect of sOMF on glioma cells indicating that ROS play a causal role in producing the effect. Our findings clarify the link between the physics of magnetic stimulation and its mechanism of anticancer action, facilitating the development of a potential new safe noninvasive device-based treatment for GBM and other gliomas.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationNot supplied

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthLowConfidence: 66% · Peer reviewed: yes

Main findings

Outcomes measured

Reactive oxygen species (ROS) / superoxide levels
Cytotoxicity / cancer cell death (oncolysis) in human glioma cells in vitro
Tumor shrinkage in GBM in vivo
Reversal of cytotoxicity by antioxidant (Trolox)

Limitations

Magnetic field parameters (e.g., frequency, intensity) not provided in the abstract
Sample size and detailed methods not provided in the abstract
In vivo model details (species, design) not provided in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "wearable EMF device generating spinning oscillating magnetic fields (sOMF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Reactive oxygen species (ROS) / superoxide levels",
    "Cytotoxicity / cancer cell death (oncolysis) in human glioma cells in vitro",
    "Tumor shrinkage in GBM in vivo",
    "Reversal of cytotoxicity by antioxidant (Trolox)"
  ],
  "main_findings": "Spinning oscillating magnetic fields (sOMF) produced cytotoxicity in two types of human glioma cells associated with a critical rise in superoxide. Trolox reversed the cytotoxic effect, supporting a causal role for ROS. The authors also report sOMF shrank GBM tumors in vivo.",
  "effect_direction": "harm",
  "limitations": [
    "Magnetic field parameters (e.g., frequency, intensity) not provided in the abstract",
    "Sample size and detailed methods not provided in the abstract",
    "In vivo model details (species, design) not provided in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "spinning oscillating magnetic fields",
    "magnetic stimulation",
    "EMF device",
    "glioma",
    "GBM",
    "reactive oxygen species",
    "superoxide",
    "Trolox",
    "oxidative stress",
    "oncolysis"
  ],
  "suggested_hubs": [
    {
      "slug": "engineering",
      "weight": 0.6,
      "reason": "Describes development/characterization of a wearable EMF device and stimulation configurations/timings."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1038/s41598-023-46758-w
PubMed: 37935811

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