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Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells

2023 · Benefit · Low evidence

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BenefitLow evidencePaper 364

The authors report that specific configurations and timings of spinning oscillating magnetic field (sOMF) stimulation produced cytotoxicity in two types of human glioma cells associated with a critical rise in superoxide. Trolox reversed the cytotoxic effect,…

Study snapshot

Publicationmanual · 2023
Study typeanimal
Reported directionBenefit
Evidence ratingLow

Abstract

Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells Hambarde S, Manalo JM, Baskin DS, Sharpe MA, Helekar SA. Spinning magnetic field patterns that cause oncolysis by oxidative stress in glioma cells. Sci Rep. 2023 Nov 7;13(1):19264. doi: 10.1038/s41598-023-46758- w. Abstract Raising reactive oxygen species (ROS) levels in cancer cells to cause macromolecular damage and cell death is a promising anticancer treatment strategy. Observations that electromagnetic fields (EMF) elevate intracellular ROS and cause cancer cell death, have led us to develop a new portable wearable EMF device that generates spinning oscillating magnetic fields (sOMF) to selectively kill cancer cells while sparing normal cells in vitro and to shrink GBM tumors in vivo through a novel mechanism. Here, we characterized the precise configurations and timings of sOMF stimulation that produce cytotoxicity due to a critical rise in superoxide in two types of human glioma cells. We also found that the antioxidant Trolox reverses the cytotoxic effect of sOMF on glioma cells indicating that ROS play a causal role in producing the effect. Our findings clarify the link between the physics of magnetic stimulation and its mechanism of anticancer action, facilitating the development of a potential new safe noninvasive device-based treatment for GBM and other gliomas. Open access paper: ncbi.nlm.nih.gov

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionbenefit
PopulationHuman glioma cells (in vitro); GBM tumors (in vivo)
Sample sizeNot supplied
ExposureNot supplied
Evidence strengthLowConfidence: 66% · Peer reviewed: yes

Main findings

The authors report that specific configurations and timings of spinning oscillating magnetic field (sOMF) stimulation produced cytotoxicity in two types of human glioma cells associated with a critical rise in superoxide. Trolox reversed the cytotoxic effect, which the authors interpret as indicating a causal role for ROS; they also state the device shrank GBM tumors in vivo.

Outcomes measured

  • Reactive oxygen species (ROS) / superoxide levels
  • Glioma cell cytotoxicity / cell death (oncolysis)
  • Tumor shrinkage in vivo
  • Effect reversal by antioxidant (Trolox)

Limitations

  • No exposure metrics provided in abstract (e.g., field strength, frequency, waveform details, duration).
  • Sample size and experimental design details not reported in abstract.
  • In vivo model details (species, tumor model, controls) not described in abstract.
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "wearable EMF device (spinning oscillating magnetic fields; sOMF)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Human glioma cells (in vitro); GBM tumors (in vivo)",
  "sample_size": null,
  "outcomes": [
    "Reactive oxygen species (ROS) / superoxide levels",
    "Glioma cell cytotoxicity / cell death (oncolysis)",
    "Tumor shrinkage in vivo",
    "Effect reversal by antioxidant (Trolox)"
  ],
  "main_findings": "The authors report that specific configurations and timings of spinning oscillating magnetic field (sOMF) stimulation produced cytotoxicity in two types of human glioma cells associated with a critical rise in superoxide. Trolox reversed the cytotoxic effect, which the authors interpret as indicating a causal role for ROS; they also state the device shrank GBM tumors in vivo.",
  "effect_direction": "benefit",
  "limitations": [
    "No exposure metrics provided in abstract (e.g., field strength, frequency, waveform details, duration).",
    "Sample size and experimental design details not reported in abstract.",
    "In vivo model details (species, tumor model, controls) not described in abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.66,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "spinning oscillating magnetic fields",
    "sOMF",
    "electromagnetic fields",
    "magnetic stimulation",
    "glioma",
    "glioblastoma",
    "GBM",
    "reactive oxygen species",
    "superoxide",
    "oxidative stress",
    "Trolox",
    "oncolysis",
    "wearable device",
    "noninvasive therapy"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1038/s41598-023-46758
PubMed: Not supplied

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