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[Microwave radiation decreases the expressions of occludin and JAM-1 in rats].

Zhonghua nan ke xue = National journal of andrology · 2010 · Harm · Low evidence

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HarmLow evidencePaper 6513

Rats exposed to microwave radiation at 10, 30, or 100 mW/cm2 for 5 minutes showed significant down-regulation of testicular occludin and JAM-1 protein expression at multiple post-exposure time points (ranging from 6 hours up to 14 days, depending on dose and …

Study snapshot

PublicationZhonghua nan ke xue = National journal of andrology · 2010
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

OBJECTIVE: To explore the changes in the expressions of the tight junction related protein occludin and junctional adhesion molecule-1 (JAM-1) of the blood-testis barrier and their significance in rats after microwave radiation. METHODS: Eighty male Wistar rats were exposed to microwave radiation with average power density of 0, 10, 30 and 100 mW/cm2 for five minutes, and dynamic changes in the expressions of testicular occludin and JAM-1 were observed by Western blot and image analysis at 6 h, 1 d, 3 d, 7 d and 14 d after the radiation. RESULTS: There was a significant down-regulation in the expression of the occludin protein at 3 - 7 d, 6 h - 7 d and 6 h - 14 d (P < 0. 05), as well as in that of JAM-1 at 3 - 7 d, 1 - 7 d and 1-14 d (P < 0.05) after exposure to 10, 30 and 100 mW/cm2 microwave radiation. CONCLUSION: The decreased protein expressions of occludin and JAM-1 may play an important role in the microwave radiation induced-damage to the blood-testis barrier.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationMale Wistar rats
Sample size80
Exposuremicrowave · 5 minutes
Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Rats exposed to microwave radiation at 10, 30, or 100 mW/cm2 for 5 minutes showed significant down-regulation of testicular occludin and JAM-1 protein expression at multiple post-exposure time points (ranging from 6 hours up to 14 days, depending on dose and protein) compared with 0 mW/cm2.

Outcomes measured

  • Testicular occludin protein expression
  • Testicular JAM-1 (junctional adhesion molecule-1) protein expression
  • Blood-testis barrier (tight junction-related proteins)

Limitations

  • Microwave frequency not reported in abstract
  • No SAR or dosimetry beyond average power density reported in abstract
  • Outcome limited to protein expression markers; functional blood-testis barrier integrity not directly reported in abstract
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "5 minutes"
  },
  "population": "Male Wistar rats",
  "sample_size": 80,
  "outcomes": [
    "Testicular occludin protein expression",
    "Testicular JAM-1 (junctional adhesion molecule-1) protein expression",
    "Blood-testis barrier (tight junction-related proteins)"
  ],
  "main_findings": "Rats exposed to microwave radiation at 10, 30, or 100 mW/cm2 for 5 minutes showed significant down-regulation of testicular occludin and JAM-1 protein expression at multiple post-exposure time points (ranging from 6 hours up to 14 days, depending on dose and protein) compared with 0 mW/cm2.",
  "effect_direction": "harm",
  "limitations": [
    "Microwave frequency not reported in abstract",
    "No SAR or dosimetry beyond average power density reported in abstract",
    "Outcome limited to protein expression markers; functional blood-testis barrier integrity not directly reported in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "rats",
    "Wistar",
    "blood-testis barrier",
    "tight junction",
    "occludin",
    "JAM-1",
    "testis",
    "power density",
    "Western blot"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 20180397

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