Static Magnetic Field Induces Abnormality of Glucose Metabolism in rats' brain and results in anxiety-like behavior

Journal of chemical neuroanatomy · 2021 · Harm · Low evidence

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HarmLow evidencePaper 1233

Study snapshot

PublicationJournal of chemical neuroanatomy · 2021

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

Static Magnetic Field Induces Abnormality of Glucose Metabolism in rats' brain and results in anxiety-like behavior Tang Shuo, Ye Yumeng, Yang Leilei, Hao Yanhui, Yu Chao, Yan Hua, Xing Yuan, Jia Zhaoqian, Hu Cuicui, Zuo Hongyan, Li Yang. Static Magnetic Field Induces Abnormality of Glucose Metabolism in rats' brain and results in anxiety-like behavior. J Chem Neuroanat. 2021 Feb 4;101923. doi: 10.1016/j.jchemneu.2021.101923. Abstract In this study, fifty-four male Wistar rats were randomly divided into four groups according to the static magnetic field (SMF) intensity, namely, control, low-intensity, moderate-intensity, and high-intensity groups. The rats' whole body was exposed to a superconducting magnet exposure source. The exposure SMF intensity for the low-intensity, moderate-intensity, and high-intensity groups was 50 m T, 100 m T, and 200 m T, respectively, and the exposure time was 1 h/day for consecutive 15 days. After different exposure times, glucose metabolism in rats' brain was evaluated by micro-positron emission tomography (micro-PET), and the expression of hexokinase 1(HK1) and 6-phosphate fructokinase-1(PFK1) was detected by western blot. The exploration and locomotion abilities of the rats were evaluated by conducting open field test (OFT). Furthermore, pathological changes of rats' brain were observed under a microscope by using hematoxylin-eosin staining. PET results showed that moderate-intensity SMFs could cause fluctuant changes in glucose metabolism in rats' brain and the abnormalities were SMF intensity dependent. The expression of the two rate-limiting enzymes HK1 and PFK1 in glucose metabolism in brain significantly decreased after SMF exposure. The OFT showed that the total distance, surrounding distance, activity time, and climbing and standing times significantly decreased after SMF exposure. The main pathological changes in the brain were pyknosis, edema of neurons, and slight widening of the perivascular space, which occurred after 15 times of exposure. This study indicated that SMF exposure could lead to abnormal glucose metabolism in the brain and might result in anxiety-like behaviors. pubmed.ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationMale Wistar rats

Sample size54

Exposurestatic · 1 h/day for 15 consecutive days; intensities 50 mT, 100 mT, 200 mT (whole-body)

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Moderate-intensity static magnetic fields were reported to cause fluctuant changes in rat brain glucose metabolism, with abnormalities described as intensity-dependent. HK1 and PFK1 expression significantly decreased after SMF exposure, open-field activity measures significantly decreased, and histopathological changes (pyknosis, neuronal edema, slight widening of perivascular space) were observed after 15 exposures; authors conclude SMF exposure could lead to abnormal brain glucose metabolism and might result in anxiety-like behaviors.

Outcomes measured

Brain glucose metabolism (micro-PET)
HK1 and PFK1 expression (western blot)
Open field test measures (locomotion/exploration: total distance, surrounding distance, activity time, climbing and standing times)
Brain histopathology (H&E staining: pyknosis, neuronal edema, perivascular space widening)
Anxiety-like behavior (inferred from OFT changes)

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "static",
    "source": "superconducting magnet exposure source",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "1 h/day for 15 consecutive days; intensities 50 mT, 100 mT, 200 mT (whole-body)"
  },
  "population": "Male Wistar rats",
  "sample_size": 54,
  "outcomes": [
    "Brain glucose metabolism (micro-PET)",
    "HK1 and PFK1 expression (western blot)",
    "Open field test measures (locomotion/exploration: total distance, surrounding distance, activity time, climbing and standing times)",
    "Brain histopathology (H&E staining: pyknosis, neuronal edema, perivascular space widening)",
    "Anxiety-like behavior (inferred from OFT changes)"
  ],
  "main_findings": "Moderate-intensity static magnetic fields were reported to cause fluctuant changes in rat brain glucose metabolism, with abnormalities described as intensity-dependent. HK1 and PFK1 expression significantly decreased after SMF exposure, open-field activity measures significantly decreased, and histopathological changes (pyknosis, neuronal edema, slight widening of perivascular space) were observed after 15 exposures; authors conclude SMF exposure could lead to abnormal brain glucose metabolism and might result in anxiety-like behaviors.",
  "effect_direction": "harm",
  "limitations": [],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "static magnetic field",
    "SMF",
    "rats",
    "Wistar",
    "glucose metabolism",
    "micro-PET",
    "hexokinase 1",
    "HK1",
    "PFK1",
    "open field test",
    "anxiety-like behavior",
    "brain pathology",
    "superconducting magnet"
  ],
  "suggested_hubs": [
    {
      "slug": "animal-studies",
      "weight": 0.9,
      "reason": "Whole-body static magnetic field exposure experiment in rats assessing brain metabolism, behavior, and histology."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/j.jchemneu.2021.101923
PubMed: 33549700

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