Effect of 2.45 GHz Electromagnetic Fields on Fear Memory Extinction in Male Rats

2022 · Mixed · Low evidence

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MixedLow evidencePaper 503

Study snapshot

Publicationmanual · 2022

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Effect of 2.45 GHz Electromagnetic Fields on Fear Memory Extinction in Male Rats Dehghani Z, Mahdavi SM, Modarresi Chahardehi A, Mansouri V, Jahani Sherafat S. The Effect of 2.45 GHz Electromagnetic Fields on Fear Memory Extinction in Male Rats. J Lasers Med Sci. 2022 Nov 28;13:e52. doi: 10.34172/jlms.2022.52. Abstract Introduction: Fear memories are influenced by psychological and environmental variables. We evaluated the effect of 2.45 GHz microwave radiation on rats' fear learning and memory ability to determine the potential risks. The present study aimed to assess the impacts of corticosterone (CORT) levels on the consolidation and reconsolidation of fear conditioning memories. Methods: The rats were evaluated in contextual fear conditioning using foot shocks in both short-term (7 days) exposure and long-term (30 days) exposure. Young male Wistar rats were continually exposed to radio frequency electromagnetic field radiation for 5-6 weeks (1 h/day) with a frequency, power density, and pulse width of 2.45 GHz, 6.0 mW/cm2, and 2 ms, respectively. Several animals housed in identical conditions without exposure to radiation were monitored. Results: Based on the results, a significant increase and decrease in body weight and percentage of the freezing time were observed after the short-term group respectively. However, in the long term, we observed no significant difference in body weight, and the freezing time decreased substantially. Conclusion: As CORT levels were analyzed, long-term radiation might increase stress, which was associated with significant weight loss in rats. Open access paper: ncbi.nlm.nih.gov

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationYoung male Wistar rats

Sample sizeNot supplied

Exposuremicrowave · 2450 MHz · 1 h/day; short-term 7 days and long-term 30 days; continually exposed for 5–6 weeks

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In the short-term exposure group, body weight significantly increased while freezing time percentage significantly decreased. In the long-term, there was no significant difference in body weight, and freezing time decreased substantially. The authors conclude that long-term radiation might increase stress based on CORT analysis and associate this with significant weight loss in rats.

Outcomes measured

fear learning and memory (contextual fear conditioning; freezing time)
body weight
corticosterone (CORT) levels/stress

Limitations

Sample size not reported in the abstract
SAR not reported (only power density and pulse width provided)
Exposure description includes multiple timeframes (7 days, 30 days, and 5–6 weeks) that are not fully reconciled in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": "1 h/day; short-term 7 days and long-term 30 days; continually exposed for 5–6 weeks"
  },
  "population": "Young male Wistar rats",
  "sample_size": null,
  "outcomes": [
    "fear learning and memory (contextual fear conditioning; freezing time)",
    "body weight",
    "corticosterone (CORT) levels/stress"
  ],
  "main_findings": "In the short-term exposure group, body weight significantly increased while freezing time percentage significantly decreased. In the long-term, there was no significant difference in body weight, and freezing time decreased substantially. The authors conclude that long-term radiation might increase stress based on CORT analysis and associate this with significant weight loss in rats.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in the abstract",
    "SAR not reported (only power density and pulse width provided)",
    "Exposure description includes multiple timeframes (7 days, 30 days, and 5–6 weeks) that are not fully reconciled in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "2.45 GHz",
    "microwave radiation",
    "radiofrequency electromagnetic field",
    "rats",
    "Wistar",
    "contextual fear conditioning",
    "fear memory extinction",
    "freezing time",
    "corticosterone",
    "stress",
    "body weight",
    "power density",
    "pulse width"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.34172/jlms.2022.52
PubMed: Not supplied

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