[Changes of the expression of beta1-adrenergic receptor and M2-muscarinic acetylcholine receptor in rat hearts after high power microwave radiation].

Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases · 2005 · Harm · Low evidence

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HarmLow evidencePaper 6425

Study snapshot

PublicationZhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases · 2005

Study typeanimal

Reported directionHarm

Evidence ratingLow

Abstract

OBJECTIVE: To investigate the effect of high power microwave (HPM) radiation on the expression of beta(1)-adrenergic receptor (beta(1)-AR) and M(2)-muscarinic acetylcholine receptor (M(2)-AchR) in cardiomyocytes. METHODS: S-band HPM device of mean power density 2 approximately 90 mW/cm(2) was used to irradiate 150 healthy Wistar male rats. Immunohistochemistry and image analysis were used to study the pathological characteristics of heart tissue and the expression of beta(1)-AR and M(2)-AchR. RESULTS: Radiation of over 10 mW/cm(2) made myocardial fibers disordered in arrangement, degeneration even sarcoplasm condensation, Pace cells necrosis, and Purkinje cells lysis in a dose-dependent manner (r = 0.968, P < 0.05). beta(1)-AR expression in endocardium, membrane and cytoplasm of myocardium of left ventricle was increased on d1 after radiation, peaked on d3 (P < 0.05) and recovered on d14. M(2)-AchR expression was peaked on d1 (P < 0.01) and recovered on d14. CONCLUSION: Certain degree intensity of HPM radiation may cause heart injury, and increased expressions of beta(1)-AR and M(2)-AchR, which may play an important role in the pathophysiology of heart injury induced by HPM.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionharm

PopulationHealthy Wistar male rats

Sample size150

Exposuremicrowave

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

In rats exposed to S-band high power microwave radiation (mean power density ~2 to 90 mW/cm^2), exposures over 10 mW/cm^2 were associated with dose-dependent myocardial structural injury (r=0.968, P<0.05). beta1-AR expression increased on day 1 post-radiation, peaked on day 3 (P<0.05), and returned to baseline by day 14; M2-AchR expression peaked on day 1 (P<0.01) and recovered by day 14.

Outcomes measured

Heart tissue pathology (myocardial fiber disorder/degeneration, sarcoplasm condensation, Pace cell necrosis, Purkinje cell lysis)
beta1-adrenergic receptor (beta1-AR) expression in myocardium
M2-muscarinic acetylcholine receptor (M2-AchR) expression in myocardium

Limitations

Exposure frequency not reported beyond 'S-band'
Exposure duration not reported
No SAR reported
Animal study; generalizability to humans is uncertain

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": "high power microwave (HPM) device (S-band)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Healthy Wistar male rats",
  "sample_size": 150,
  "outcomes": [
    "Heart tissue pathology (myocardial fiber disorder/degeneration, sarcoplasm condensation, Pace cell necrosis, Purkinje cell lysis)",
    "beta1-adrenergic receptor (beta1-AR) expression in myocardium",
    "M2-muscarinic acetylcholine receptor (M2-AchR) expression in myocardium"
  ],
  "main_findings": "In rats exposed to S-band high power microwave radiation (mean power density ~2 to 90 mW/cm^2), exposures over 10 mW/cm^2 were associated with dose-dependent myocardial structural injury (r=0.968, P<0.05). beta1-AR expression increased on day 1 post-radiation, peaked on day 3 (P<0.05), and returned to baseline by day 14; M2-AchR expression peaked on day 1 (P<0.01) and recovered by day 14.",
  "effect_direction": "harm",
  "limitations": [
    "Exposure frequency not reported beyond 'S-band'",
    "Exposure duration not reported",
    "No SAR reported",
    "Animal study; generalizability to humans is uncertain"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "high power microwave",
    "HPM",
    "S-band",
    "rat",
    "heart injury",
    "cardiomyocytes",
    "beta1-adrenergic receptor",
    "M2 muscarinic acetylcholine receptor",
    "immunohistochemistry",
    "dose-dependent"
  ],
  "suggested_hubs": [
    {
      "slug": "occupational-exposure",
      "weight": 0.55,
      "reason": "Published in an industrial hygiene/occupational diseases journal and uses high-power microwave exposure relevant to occupational settings."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 16124889

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