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[Changes of rat testicular germ cell apoptosis after high power microwave radiation].

Zhonghua nan ke xue = National journal of andrology · 2004 · Mixed · Low evidence

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MixedLow evidencePaper 6412

Compared with controls, apoptotic germ cells were significantly increased at 6 h, 24 h, and 48 h after 5 min exposure at 10 or 20 mW/cm2 (P<0.01), with a reported peak at 6 h after 10 mW/cm2. Other exposure/timepoint groups did not differ significantly from c…

Study snapshot

PublicationZhonghua nan ke xue = National journal of andrology · 2004
Study typeanimal
Reported directionMixed
Evidence ratingLow

Abstract

OBJECTIVE: To study the effect of high power microwave (HPM) radiation on the testicular germ cell apoptosis. METHODS: One hundred and twenty-five Spraque-Dawley rats were randomly divided into two groups, unexposed control group and experimental group(further divided into four subgroups: 10 mW/cm2 5 min, 10 mW/cm2 10 min, 20 mw/cm2 5 min, and 20 mW/cm2 10 min), and then the experimental group was radiated with S wave band of 10 mW/cm2, 20 mW/cm2 high power microwave for 5 or 10 min. Testicular samples were taken at 6 h, 24 h, 48 h, 72 h and 5 d after radiation and separately studied. At the end of the process, testicular germ cell apoptosis was detected by in situ terminal deoxynucleotityl transferase mediated dUTP nick end labeling (TUNEL). RESULTS: The number of apoptotic cells of the 6 h, 24 h and 48 h experimental groups at 5 min after 10 and 20 mW/cm2 radiation was remarkably larger than that of the controls (P < 0.01), especially after 10 mW/cm2 radiation, the number of the 6 h group reached the peak (161.27 +/- 5.90) /5 convoluted seminiferous tubules. The changes in the other experimental groups had no significant difference compared with the controls (P > 0.05). CONCLUSION: HPM can increase germ cell apoptosis of the rat testis, which is related to the time of radiation and sample acquisition. In the condition of the present test, 5 minutes of HPM radiation may significantly enhance testicular germ cell apoptosis and damage, which in turn may influence the reproductive function of the rats.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionmixed
PopulationSprague-Dawley rats
Sample size125
Exposuremicrowave (S wave band) · 5 or 10 min (subgroups: 10 mW/cm2 for 5 or 10 min; 20 mW/cm2 for 5 or 10 min)
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

Compared with controls, apoptotic germ cells were significantly increased at 6 h, 24 h, and 48 h after 5 min exposure at 10 or 20 mW/cm2 (P<0.01), with a reported peak at 6 h after 10 mW/cm2. Other exposure/timepoint groups did not differ significantly from controls (P>0.05).

Outcomes measured

  • Testicular germ cell apoptosis (TUNEL)

Limitations

  • Microwave frequency not reported (only described as S wave band).
  • No SAR or dosimetry details beyond incident power density (mW/cm2).
  • Outcomes limited to apoptosis; reproductive function effects are suggested but not directly measured in the reported results.
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "microwave (S wave band)",
    "source": "high power microwave radiation",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "5 or 10 min (subgroups: 10 mW/cm2 for 5 or 10 min; 20 mW/cm2 for 5 or 10 min)"
  },
  "population": "Sprague-Dawley rats",
  "sample_size": 125,
  "outcomes": [
    "Testicular germ cell apoptosis (TUNEL)"
  ],
  "main_findings": "Compared with controls, apoptotic germ cells were significantly increased at 6 h, 24 h, and 48 h after 5 min exposure at 10 or 20 mW/cm2 (P<0.01), with a reported peak at 6 h after 10 mW/cm2. Other exposure/timepoint groups did not differ significantly from controls (P>0.05).",
  "effect_direction": "mixed",
  "limitations": [
    "Microwave frequency not reported (only described as S wave band).",
    "No SAR or dosimetry details beyond incident power density (mW/cm2).",
    "Outcomes limited to apoptosis; reproductive function effects are suggested but not directly measured in the reported results."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "high power microwave",
    "S band",
    "rat",
    "testis",
    "germ cell",
    "apoptosis",
    "TUNEL",
    "power density",
    "time course"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 15267200

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