Induction of micronuclei in human lymphocytes exposed in vitro to microwave radiation.

Mutation research · 2000 · Harm · Low evidence

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HarmLow evidencePaper 6366

For both radiation frequencies (2.45 and 7.7 GHz), micronuclei were induced compared with control cultures at a power density of 30 mW/cm^2 after 30 and 60 min exposures.

Study snapshot

PublicationMutation research · 2000

Study typein_vitro

Reported directionHarm

Evidence ratingLow

Abstract

Increasing applications of electromagnetic fields are of great concern with regard to public health. Several in vitro studies have been conducted to detect effects of microwave exposure on the genetic material leading to negative or questionable results. The micronucleus (MN) assay which is proved to be a useful tool for the detection of radiation exposure-induced cytogenetic damage was used in the present study to investigate the genotoxic effect of microwaves in human peripheral blood lymphocytes in vitro exposed in G(0) to electromagnetic fields with different frequencies (2.45 and 7.7GHz) and power density (10, 20 and 30mW/cm(2)) for three times (15, 30 and 60min). The results showed for both radiation frequencies an induction of micronuclei as compared to the control cultures at a power density of 30mW/cm(2) and after an exposure of 30 and 60min. Our study would indicate that microwaves are able to cause cytogenetic damage in human lymphocytes mainly for both high power density and long exposure time.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationHuman peripheral blood lymphocytes (in vitro, exposed in G(0))

Sample sizeNot supplied

Exposuremicrowave · 15, 30, and 60 min (three exposure times)

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

For both radiation frequencies (2.45 and 7.7 GHz), micronuclei were induced compared with control cultures at a power density of 30 mW/cm^2 after 30 and 60 min exposures.

Outcomes measured

Micronuclei induction (micronucleus assay)
Cytogenetic damage / genotoxic effect

Limitations

Sample size not reported in abstract
In vitro study (human lymphocytes), may not generalize to in vivo human health outcomes
Effects reported at specific higher power density (30 mW/cm^2) and longer exposure times (30–60 min); results for lower power densities/times not detailed in abstract

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "15, 30, and 60 min (three exposure times)"
  },
  "population": "Human peripheral blood lymphocytes (in vitro, exposed in G(0))",
  "sample_size": null,
  "outcomes": [
    "Micronuclei induction (micronucleus assay)",
    "Cytogenetic damage / genotoxic effect"
  ],
  "main_findings": "For both radiation frequencies (2.45 and 7.7 GHz), micronuclei were induced compared with control cultures at a power density of 30 mW/cm^2 after 30 and 60 min exposures.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract",
    "In vitro study (human lymphocytes), may not generalize to in vivo human health outcomes",
    "Effects reported at specific higher power density (30 mW/cm^2) and longer exposure times (30–60 min); results for lower power densities/times not detailed in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "electromagnetic fields",
    "human lymphocytes",
    "in vitro",
    "micronucleus assay",
    "micronuclei",
    "genotoxicity",
    "cytogenetic damage",
    "2.45 GHz",
    "7.7 GHz",
    "power density"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/s1383-5718(00)00112-1
PubMed: 11113697

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