The correlation between the frequency of micronuclei and specific chromosome aberrations in human lymphocytes exposed to microwave radiation in vitro.

Mutation research · 1992 · Harm · Low evidence

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HarmLow evidencePaper 6296

Study snapshot

PublicationMutation research · 1992

Study typein_vitro

Reported directionHarm

Evidence ratingLow

Abstract

Human whole-blood samples were exposed to continuous microwave radiation, frequency 7.7 GHz, power density 0.5, 10 and 30 mW/cm2 for 10, 30 and 60 min. A correlation between specific chromosomal aberrations and the incidence of micronuclei after in vitro exposure was observed. In all experimental conditions, the frequency of all types of chromosomal aberrations was significantly higher than in the control samples. In the irradiated samples the presence of dicentric and ring chromosomes was established. The incidence of micronuclei was also higher in the exposed samples. The results of the structural chromosome aberration test and of the micronucleus test were comparatively analyzed. The values obtained showed a positive correlation between micronuclei and specific chromosomal aberrations (acentric fragments and dicentric chromosomes). The results of the study indicate that microwave radiation causes changes in the genome of somatic human cells and that the applied tests are equally sensitive for the detection of the genotoxicity of microwaves.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro

Effect directionharm

PopulationHuman whole-blood samples (lymphocytes) in vitro

Sample sizeNot supplied

Exposuremicrowave · 7700 MHz · 10, 30 and 60 min

Evidence strengthLowConfidence: 78% · Peer reviewed: yes

Main findings

Human whole-blood samples exposed in vitro to continuous 7.7 GHz microwave radiation at 0.5, 10, and 30 mW/cm2 for 10, 30, and 60 minutes showed significantly higher frequencies of chromosomal aberrations than controls, including dicentric and ring chromosomes. Micronuclei incidence was also higher in exposed samples, and micronuclei values positively correlated with specific aberrations (acentric fragments and dicentric chromosomes).

Outcomes measured

Micronuclei frequency
Chromosomal aberrations (overall frequency)
Dicentric chromosomes
Ring chromosomes
Acentric fragments
Correlation between micronuclei and specific chromosomal aberrations

Limitations

Sample size not reported in the abstract.
In vitro study; relevance to in vivo human health outcomes is not established in the abstract.
No dosimetry details beyond power density and exposure duration (e.g., SAR, temperature control) are provided in the abstract.

View raw extracted JSON

{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 7700,
    "sar_wkg": null,
    "duration": "10, 30 and 60 min"
  },
  "population": "Human whole-blood samples (lymphocytes) in vitro",
  "sample_size": null,
  "outcomes": [
    "Micronuclei frequency",
    "Chromosomal aberrations (overall frequency)",
    "Dicentric chromosomes",
    "Ring chromosomes",
    "Acentric fragments",
    "Correlation between micronuclei and specific chromosomal aberrations"
  ],
  "main_findings": "Human whole-blood samples exposed in vitro to continuous 7.7 GHz microwave radiation at 0.5, 10, and 30 mW/cm2 for 10, 30, and 60 minutes showed significantly higher frequencies of chromosomal aberrations than controls, including dicentric and ring chromosomes. Micronuclei incidence was also higher in exposed samples, and micronuclei values positively correlated with specific aberrations (acentric fragments and dicentric chromosomes).",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in the abstract.",
    "In vitro study; relevance to in vivo human health outcomes is not established in the abstract.",
    "No dosimetry details beyond power density and exposure duration (e.g., SAR, temperature control) are provided in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.78,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "microwave radiation",
    "7.7 GHz",
    "in vitro",
    "human lymphocytes",
    "whole blood",
    "micronuclei",
    "chromosomal aberrations",
    "dicentric chromosomes",
    "ring chromosomes",
    "acentric fragments",
    "genotoxicity"
  ],
  "suggested_hubs": []
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1016/0165-7992(92)90006-4
PubMed: 1371840

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