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Japanese encephalitis virus (JEV): potentiation of lethality in mice by microwave radiation.

Bioelectromagnetics · 1991 · Harm · Low evidence

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HarmLow evidencePaper 6286

In mice administered Japanese encephalitis virus, 2.45-GHz continuous-wave microwave exposure (10 min) at 10–50 mW/cm2 produced a dose-dependent increase in JEV-induced lethality. Four daily exposures at 10 or 50 mW/cm2 (SARS approximately 24–98 W/kg) did not…

Study snapshot

PublicationBioelectromagnetics · 1991
Study typeanimal
Reported directionHarm
Evidence ratingLow

Abstract

The expression of Japanese Encephalitis Virus (JEV) lethality in mice requires entry of the virus into the central nervous system. This entry is presumably through the capillary endothelial cells (CEC), because entry between CECs is inhibited by bands of circumferential tight-junctions. A viremic stage occurs during the first 4 to 5 days after JEV administration in mice, and both microwave radiation (2.45-GHz, continuous wave, 10-min exposure) and hypercarbia were employed to increase CEC permeability to JEV. Exposure to microwaves at power densities of 10-50 mW/cm2 resulted in a dose-dependent increase in JEV-induced lethality. Mice did not become tolerant or sensitized to microwave potentiation of JEV-induced mortality because 4 daily exposures at 10 or 50 mW/cm2 (SARS, approximately 24-98 W/kg) did not alter the lethality pattern to subsequent microwave radiation of JEV-exposed animals. Similarly, hypercarbia (5, 10, and 20% CO2) was observed to produce a dose-dependent increase in JEV-induced lethality. Both microwave radiation and hypercarbia are thought to promote pinocytosis in CNS capillary endothelial cells. This may be one mechanism by which they enhance JEV-induced lethality in adult Swiss-Cox mice.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal
Effect directionharm
PopulationAdult Swiss-Cox mice
Sample sizeNot supplied
Exposuremicrowave · 2450 MHz · continuous wave; 10-min exposure; also 4 daily exposures at 10 or 50 mW/cm2
Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

In mice administered Japanese encephalitis virus, 2.45-GHz continuous-wave microwave exposure (10 min) at 10–50 mW/cm2 produced a dose-dependent increase in JEV-induced lethality. Four daily exposures at 10 or 50 mW/cm2 (SARS approximately 24–98 W/kg) did not change the lethality pattern to subsequent microwave radiation in JEV-exposed animals.

Outcomes measured

  • JEV-induced lethality/mortality

Limitations

  • Sample size not reported in abstract.
  • Details of randomization/blinding and control conditions not described in abstract.
  • Mechanistic interpretation (e.g., pinocytosis/CEC permeability) is stated as a hypothesis in the abstract.
View raw extracted JSON
{
  "study_type": "animal",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": "continuous wave; 10-min exposure; also 4 daily exposures at 10 or 50 mW/cm2"
  },
  "population": "Adult Swiss-Cox mice",
  "sample_size": null,
  "outcomes": [
    "JEV-induced lethality/mortality"
  ],
  "main_findings": "In mice administered Japanese encephalitis virus, 2.45-GHz continuous-wave microwave exposure (10 min) at 10–50 mW/cm2 produced a dose-dependent increase in JEV-induced lethality. Four daily exposures at 10 or 50 mW/cm2 (SARS approximately 24–98 W/kg) did not change the lethality pattern to subsequent microwave radiation in JEV-exposed animals.",
  "effect_direction": "harm",
  "limitations": [
    "Sample size not reported in abstract.",
    "Details of randomization/blinding and control conditions not described in abstract.",
    "Mechanistic interpretation (e.g., pinocytosis/CEC permeability) is stated as a hypothesis in the abstract."
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "Japanese encephalitis virus",
    "mice",
    "microwave radiation",
    "2.45 GHz",
    "continuous wave",
    "power density",
    "SAR",
    "capillary endothelial cells",
    "blood-brain barrier permeability",
    "lethality",
    "hypercarbia"
  ],
  "suggested_hubs": [
    {
      "slug": "rf-microwave-animal-studies",
      "weight": 0.9,
      "reason": "Animal experiment assessing 2.45 GHz microwave exposure effects on lethality in mice."
    }
  ]
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1002/bem.2250120603
PubMed: 1750827

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