Stability of solutions of doxorubicin and epirubicin in plastic minibags for intravesical use after storage at -20 degrees C and thawing by microwave radiation.

{
  "study_type": "other",
  "exposure": {
    "band": null,
    "source": "microwave radiation (thawing)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": null,
  "sample_size": null,
  "outcomes": [
    "Drug concentration/content stability after freezing and thawing (doxorubicin, epirubicin)"
  ],
  "main_findings": "Doxorubicin and epirubicin solutions stored at -20°C and thawed either at room temperature or by microwave radiation showed no loss of content after at least 2 weeks (doxorubicin) and 4 weeks (epirubicin). Refreezing and re-thawing doxorubicin five weeks later resulted in only a slight decrease in content.",
  "effect_direction": "no_effect",
  "limitations": [
    "No sample size reported in abstract",
    "Microwave exposure parameters (e.g., frequency, power, duration) not reported",
    "Study focuses on pharmaceutical stability rather than biological/health outcomes"
  ],
  "evidence_strength": "insufficient",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "doxorubicin",
    "epirubicin",
    "intravesical",
    "plastic minibags",
    "-20°C storage",
    "freezing",
    "thawing",
    "microwave radiation",
    "HPLC",
    "TLC",
    "stability"
  ],
  "suggested_hubs": []
}