Pharmacokinetics of the doxorubicin magnetic nanoconjugate in mice. Effects of the nonuniform stationary magnetic field.

Ukrains'kyi biokhimichnyi zhurnal (1999 ) · 2005 · Mixed · Low evidence

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MixedLow evidencePaper 3579

Study snapshot

PublicationUkrains'kyi biokhimichnyi zhurnal (1999 ) · 2005

Study typeanimal

Reported directionMixed

Evidence ratingLow

Abstract

Pharmacokinetics of the doxorubicin (DOX) conjugates with magnetite nanoparticles of the core/ shell type in mice following i.v. injection in a dose of 12.5 microg Fe/g tissue w/w was studied using electron spin resonance technique (ESR). Conjugation of the DOX with magnetic nanoparticles was shown to considerably decrease DOX bioavailability in the heart and kidney tissues compared to the free DOX. A non-uniform stationary magnetic field B of 210 mT and [deltaB] of 200 mT/cm was found to be efficient in increasing DOX conjugate bioavailability in the target site. The magnetic field was also found to inhibit conjugate accumulation in the liver resulted in the increased bioavailability of the conjugates in the blood. The phenomenon can be associated with in vivo inhibition of the phagocytic activity of the immunocompetent cells upon application of magnetic fields. Morphometry data in agreement with pharmacokinetic data revealed a decrease in the conjugate concentration in the liver tissue and cells as well as the relative decrease in conjugate concentration in the Kupffer cells compared to hepatocytes upon application of magnetic fields.

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Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typeanimal

Effect directionmixed

PopulationMice

Sample sizeNot supplied

ExposureNot supplied

Evidence strengthLowConfidence: 74% · Peer reviewed: yes

Main findings

After i.v. injection, conjugation of doxorubicin with magnetite nanoparticles decreased DOX bioavailability in heart and kidney compared with free DOX. Application of a non-uniform stationary magnetic field (B 210 mT; gradient 200 mT/cm) increased DOX conjugate bioavailability at the target site and inhibited conjugate accumulation in the liver, with increased bioavailability in blood. Morphometry findings were reported to align with pharmacokinetic results, showing decreased conjugate concentration in liver tissue/cells and relatively decreased concentration in Kupffer cells compared with hepatocytes under magnetic field application.

Outcomes measured

Pharmacokinetics/bioavailability of doxorubicin (DOX) magnetite nanoparticle conjugates in tissues (heart, kidney, liver, blood, target site)
Conjugate accumulation in liver
Morphometry of liver cells (Kupffer cells vs hepatocytes)

Limitations

Sample size not reported in abstract
Exposure duration/timing relative to injection not reported in abstract
Outcomes focused on drug distribution rather than health endpoints
Mechanistic explanation (phagocytic inhibition) is suggested but not directly established in the abstract

View raw extracted JSON

{
  "study_type": "animal",
  "exposure": {
    "band": null,
    "source": "static magnetic field",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": null
  },
  "population": "Mice",
  "sample_size": null,
  "outcomes": [
    "Pharmacokinetics/bioavailability of doxorubicin (DOX) magnetite nanoparticle conjugates in tissues (heart, kidney, liver, blood, target site)",
    "Conjugate accumulation in liver",
    "Morphometry of liver cells (Kupffer cells vs hepatocytes)"
  ],
  "main_findings": "After i.v. injection, conjugation of doxorubicin with magnetite nanoparticles decreased DOX bioavailability in heart and kidney compared with free DOX. Application of a non-uniform stationary magnetic field (B 210 mT; gradient 200 mT/cm) increased DOX conjugate bioavailability at the target site and inhibited conjugate accumulation in the liver, with increased bioavailability in blood. Morphometry findings were reported to align with pharmacokinetic results, showing decreased conjugate concentration in liver tissue/cells and relatively decreased concentration in Kupffer cells compared with hepatocytes under magnetic field application.",
  "effect_direction": "mixed",
  "limitations": [
    "Sample size not reported in abstract",
    "Exposure duration/timing relative to injection not reported in abstract",
    "Outcomes focused on drug distribution rather than health endpoints",
    "Mechanistic explanation (phagocytic inhibition) is suggested but not directly established in the abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "doxorubicin",
    "magnetite nanoparticles",
    "magnetic nanoconjugate",
    "pharmacokinetics",
    "electron spin resonance",
    "static magnetic field",
    "non-uniform magnetic field",
    "bioavailability",
    "liver",
    "Kupffer cells"
  ],
  "suggested_hubs": [
    {
      "slug": "static-magnetic-fields",
      "weight": 0.9,
      "reason": "Study applies a non-uniform stationary (static) magnetic field (210 mT; 200 mT/cm) in vivo."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: Not supplied
PubMed: 16846074

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