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Rat lymphocytes in cell culture exposed to 2450 MHz (CW) microwave radiation.

The Journal of microwave power · 1977 · No effect · Low evidence

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No effectLow evidencePaper 6102

Rat lymphocyte cultures exposed to 2450 MHz continuous-wave microwave radiation at 5, 10, or 20 mW/cm2 (absorption rates 0.7, 1.4, or 2.8 mW/g) for 4, 24, or 44 hours showed no significant differences in tritiated thymidine uptake compared with control cultur…

Study snapshot

PublicationThe Journal of microwave power · 1977
Study typein_vitro
Reported directionNo effect
Evidence ratingLow

Abstract

Rat lymphocytes were exposed to continuous wave microwave radiation at a frequency of 2450 MHz at intensities of 5, 10 and 20 mW/cm2. The corresponding rates of absorption of energy were determined to be 0.7, 1.4 and 2.8 mW/g. The lymphocytes were exposed for 4, 24 or 44 h either with or without the addition of a mitogen (phytohemagglutinin). The transformation of lymphocytes into lyphoblasts was monitored by the addition of tritiated thymidine. No significant differences (P less than .05) were found in the uptake of tritiated thymidine between exposed and control cultures.

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AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typein_vitro
Effect directionno_effect
PopulationRat lymphocytes in cell culture
Sample sizeNot supplied
Exposuremicrowave · 2450 MHz · 4, 24, or 44 h
Evidence strengthLowConfidence: 86% · Peer reviewed: yes

Main findings

Rat lymphocyte cultures exposed to 2450 MHz continuous-wave microwave radiation at 5, 10, or 20 mW/cm2 (absorption rates 0.7, 1.4, or 2.8 mW/g) for 4, 24, or 44 hours showed no significant differences in tritiated thymidine uptake compared with control cultures, with or without phytohemagglutinin.

Outcomes measured

  • Lymphocyte transformation into lymphoblasts (tritiated thymidine uptake)

Limitations

  • Sample size not reported in abstract
  • Only one biological endpoint reported (tritiated thymidine uptake/lymphocyte transformation)
  • In vitro cell culture model; generalizability to in vivo outcomes not addressed in abstract
View raw extracted JSON
{
  "study_type": "in_vitro",
  "exposure": {
    "band": "microwave",
    "source": null,
    "frequency_mhz": 2450,
    "sar_wkg": null,
    "duration": "4, 24, or 44 h"
  },
  "population": "Rat lymphocytes in cell culture",
  "sample_size": null,
  "outcomes": [
    "Lymphocyte transformation into lymphoblasts (tritiated thymidine uptake)"
  ],
  "main_findings": "Rat lymphocyte cultures exposed to 2450 MHz continuous-wave microwave radiation at 5, 10, or 20 mW/cm2 (absorption rates 0.7, 1.4, or 2.8 mW/g) for 4, 24, or 44 hours showed no significant differences in tritiated thymidine uptake compared with control cultures, with or without phytohemagglutinin.",
  "effect_direction": "no_effect",
  "limitations": [
    "Sample size not reported in abstract",
    "Only one biological endpoint reported (tritiated thymidine uptake/lymphocyte transformation)",
    "In vitro cell culture model; generalizability to in vivo outcomes not addressed in abstract"
  ],
  "evidence_strength": "low",
  "confidence": 0.86,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "rat lymphocytes",
    "cell culture",
    "microwave radiation",
    "2450 MHz",
    "continuous wave",
    "mW/cm2",
    "energy absorption",
    "phytohemagglutinin",
    "mitogen",
    "tritiated thymidine",
    "lymphocyte transformation"
  ],
  "suggested_hubs": []
}
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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.1080/16070658.1977.11689038
PubMed: 243542

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