Chronic Drug-Resistant Cystitis Treated with a Sequence of Modulated Extremely Low-Frequency Electromagnetic Fields: A Randomized Study of 148 Cases.

Journal of clinical medicine · 2024 · Benefit · Moderate evidence

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BenefitModerate evidencePaper 5852

Study snapshot

PublicationJournal of clinical medicine · 2024

Study typerandomized_trial

Reported directionBenefit

Evidence ratingModerate

Abstract

This study investigated the effects of sequenced electromagnetic fields, modulated at extremely low frequencies and intensities, in the treatment of drug-resistant ()-induced chronic bacterial cystitis. A total of 148 female participants, aged 18 to 80 years diagnosed with chronic bacterial cystitis caused by drug-resistant , were recruited for this study. Participants were randomly assigned to two groups: an experimental group (n = 74) with osteopathic palpation and assessment treated with a sequence of electromagnetic fields, and a control group (n = 74) receiving a placebo treatment. Both groups were assessed at this study's outset, 4 weeks after eight applications, and at 12 weeks for symptomatic presentation and laboratory parameters. After 4 weeks of treatment, a significant difference was observed between the two groups regarding D-DIMER levels, IL-6 levels, erythrocyte levels, leukocyte levels, and levels ( < 0.001). By the 12th week, the experimental group continued to exhibit a significant reduction in the examined parameters compared to the control group ( < 0.001). Additionally, the treatment did not induce any side effects in the patients in the experimental group. Treatment with coherently sequenced electromagnetic fields, modulated at an extremely low frequency and intensity, not only appears to provide an effective alternative for the symptoms of chronic bacterial cystitis caused by drug-resistant but also demonstrates a potent antibacterial effect.

Machine Enhanced Logic

AI evidence extraction

Structured fields below were generated from the paper’s abstract and metadata to make the evidence easier to inspect. Automated extraction may be incomplete or incorrect; verify important details against the original paper.

Study typerandomized_trial

Effect directionbenefit

PopulationFemale participants aged 18–80 years with chronic bacterial cystitis caused by drug-resistant bacteria

Sample size148

ExposureELF · Eight applications over 4 weeks; follow-up at 12 weeks

Evidence strengthModerateConfidence: 74% · Peer reviewed: yes

Main findings

In a randomized study of 148 women, the group treated with a sequence of extremely low-frequency, low-intensity electromagnetic fields showed significant differences versus placebo at 4 weeks in D-DIMER, IL-6, erythrocyte, leukocyte, and bacterial levels (p < 0.001), with reductions maintained at 12 weeks (p < 0.001). No side effects were reported in the experimental group.

Outcomes measured

Symptomatic presentation
Laboratory parameters
D-DIMER levels
IL-6 levels
Erythrocyte levels
Leukocyte levels
Bacterial levels (unspecified)
Side effects/adverse events

Limitations

Specific frequencies and field intensities were not reported in the abstract.
The causative organism and the exact laboratory measure described as “levels” were not specified in the abstract.
Details on randomization, blinding, and the placebo procedure were not provided in the abstract.
Outcome measurement methods for symptoms and laboratory parameters were not described in the abstract.

View raw extracted JSON

{
  "study_type": "randomized_trial",
  "exposure": {
    "band": "ELF",
    "source": "therapeutic electromagnetic field device (sequenced/modulated)",
    "frequency_mhz": null,
    "sar_wkg": null,
    "duration": "Eight applications over 4 weeks; follow-up at 12 weeks"
  },
  "population": "Female participants aged 18–80 years with chronic bacterial cystitis caused by drug-resistant bacteria",
  "sample_size": 148,
  "outcomes": [
    "Symptomatic presentation",
    "Laboratory parameters",
    "D-DIMER levels",
    "IL-6 levels",
    "Erythrocyte levels",
    "Leukocyte levels",
    "Bacterial levels (unspecified)",
    "Side effects/adverse events"
  ],
  "main_findings": "In a randomized study of 148 women, the group treated with a sequence of extremely low-frequency, low-intensity electromagnetic fields showed significant differences versus placebo at 4 weeks in D-DIMER, IL-6, erythrocyte, leukocyte, and bacterial levels (p < 0.001), with reductions maintained at 12 weeks (p < 0.001). No side effects were reported in the experimental group.",
  "effect_direction": "benefit",
  "limitations": [
    "Specific frequencies and field intensities were not reported in the abstract.",
    "The causative organism and the exact laboratory measure described as “levels” were not specified in the abstract.",
    "Details on randomization, blinding, and the placebo procedure were not provided in the abstract.",
    "Outcome measurement methods for symptoms and laboratory parameters were not described in the abstract."
  ],
  "evidence_strength": "moderate",
  "confidence": 0.74,
  "peer_reviewed_likely": "yes",
  "keywords": [
    "extremely low-frequency",
    "ELF-EMF",
    "modulated electromagnetic fields",
    "sequenced electromagnetic fields",
    "randomized",
    "placebo",
    "chronic bacterial cystitis",
    "drug-resistant",
    "IL-6",
    "D-dimer"
  ],
  "suggested_hubs": [
    {
      "slug": "therapeutic-emf",
      "weight": 0.9,
      "reason": "Study evaluates a therapeutic application of modulated extremely low-frequency electromagnetic fields in a randomized placebo-controlled design."
    }
  ]
}

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AI-extracted fields are generated from the abstract and metadata and may be incomplete or incorrect. This material is for informational purposes and is not medical advice.

Identifiers and source

DOI: 10.3390/jcm13092639
PubMed: 38731168

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